Rama Rao Rahul, Reddy Anish Bandalore Satheesha, P Dhanushia, Koul Abhay
Psychiatry, Mysore Medical College and Research Institute, Mysuru, IND.
Psychosis Studies, King's College London, London, GBR.
Cureus. 2024 Feb 20;16(2):e54534. doi: 10.7759/cureus.54534. eCollection 2024 Feb.
Schizencephaly is a rare congenital anomaly characterized by the formation of abnormal clefts in the brain. Despite the association of psychotic symptoms with various brain abnormalities or insults, their occurrence in individuals with schizencephaly is relatively infrequent. The association of bipolar disorder, with or without psychosis, with schizencephaly is rarer. A systematic search on PubMed using "Schizencephaly AND Bipolar Disorder" yielded only four case studies specifically addressing the connection between these two conditions. Here, we present a case of a 22-year-old male patient with a history of childhood seizures who developed first episode psychosis along with manic symptoms and was found to have closed-lip schizencephaly.
脑裂畸形是一种罕见的先天性异常，其特征是大脑中形成异常裂隙。尽管精神症状与各种脑异常或损伤有关，但在脑裂畸形患者中其出现相对较少。双相情感障碍（伴或不伴精神病性症状）与脑裂畸形的关联更为罕见。在PubMed上使用“脑裂畸形与双相情感障碍”进行系统检索，仅得到四项专门探讨这两种疾病之间关联的病例研究。在此，我们报告一例22岁男性患者，该患者有儿童期癫痫病史，出现了首次发作的精神病性症状及躁狂症状，经检查发现患有闭合性唇脑裂畸形。
