Department of Psychiatry, Chang Gung Memorial Hospital at Keelung, Taiwan.
Gen Hosp Psychiatry. 2012 Nov-Dec;34(6):702.e1-3. doi: 10.1016/j.genhosppsych.2011.12.004. Epub 2012 Jan 27.
There is compelling evidence for an association between structural brain deformities and psychiatric disorders. We report the case of an adolescent boy who was diagnosed with both attention-deficit/hyperactivity disorder and Tourette's syndrome. A full-blown manic episode occurred when he was 13 years old. During his admission to a psychiatric ward, closed-lip schizencephaly in the left frontal lobe and the right parietal lobe was identified through brain imaging. Effective control of his manic symptoms was achieved with quetiapine monotherapy within 3 weeks. This case report implies that the pathophysiology of psychiatric disorders, especially in young patients with multiple comorbid conditions, may be associated with abnormalities in the anatomical and functional development of the brain.
有确凿的证据表明结构性脑畸形与精神疾病之间存在关联。我们报告了一例患有注意力缺陷/多动障碍和妥瑞氏症的青少年男孩的病例。他在 13 岁时出现了全面性躁狂发作。在他被收治入精神病病房期间，通过脑部成像发现他的左额叶和右顶叶存在闭合性脑裂畸形。在 3 周内，他通过喹硫平单药治疗有效地控制了他的躁狂症状。本病例报告提示，精神疾病的病理生理学，尤其是在伴有多种合并症的年轻患者中，可能与大脑解剖和功能发育异常有关。
