Alexander R C, Patkar A A, Lapointe J S, Flynn S W, Honer W G
Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA.
J Neurol Neurosurg Psychiatry. 1997 Sep;63(3):373-5. doi: 10.1136/jnnp.63.3.373.
Schizencephaly is a rare disorder of brain development resulting in the formation of abnormal unilateral or bilateral clefts in the cerebral hemispheres. It is often accompanied by partial seizures, mental retardation, and hemiparesis. Two patients are described with clear psychotic symptoms with either unilateral or bilateral schizencephaly. The implications of the association between schizencephaly and psychosis in these patients for understanding the biology of the psychoses are discussed.
脑裂畸形是一种罕见的脑发育障碍，可导致大脑半球形成异常的单侧或双侧裂隙。它常伴有部分性癫痫、智力发育迟缓及偏瘫。本文描述了两名患有单侧或双侧脑裂畸形且伴有明显精神病症状的患者。并讨论了这些患者中脑裂畸形与精神病之间的关联对于理解精神病生物学机制的意义。
