St John Sutton M G, Tajik A J, Mercier L A, Seward J B, Giuliani E R, Ritman E L
Circulation. 1979 Nov;60(5):1082-90. doi: 10.1161/01.cir.60.5.1082.
Left ventricular function in 53 patients with secundum atrial septal defect was assessed by computer-assisted analysis of the left ventricular echocardiogram and by cardiac catheterization. The patients were divided into two groups, those younger and those older than 60 years, to investigate the effect of aging on left ventricular function. Cavity size was significantly smaller than normal (p less than 0.01) and septal motion was abnormal in 86%, but values for cardiac index, left ventricular end-diastolic pressure, velocity of circumferential fiber shortening, left ventricular filling rate, and duration of rapid filling were normal in both groups. Regional dynamics assessed in terms of peak rates of systolic thickening and diastolic thinning of the septum and posterior wall were also normal in both groups. We concluded that, although left ventricular minor dimensions are small, and septal motion is reversed in the majority of patients with atrial septal defect, left ventricular function is normal, and it does not appear to deteriorate with increased age, pulmonary hypertension, or the presence of right ventricular failure. The abnormal septal motion appears to be compensated for by enhanced septal and posterior wall percentage thickening.
通过计算机辅助分析左心室超声心动图以及心脏导管插入术，对53例继发孔型房间隔缺损患者的左心室功能进行了评估。患者被分为两组，年龄小于60岁的和年龄大于60岁的，以研究衰老对左心室功能的影响。两组患者的心室腔大小均显著小于正常（p<0.01），86%的患者室间隔运动异常，但两组患者的心脏指数、左心室舒张末期压力、圆周纤维缩短速度、左心室充盈率以及快速充盈持续时间的值均正常。根据室间隔和后壁收缩期增厚峰值率和舒张期变薄峰值率评估的局部动力学在两组中也均正常。我们得出结论，尽管大多数房间隔缺损患者的左心室较小尺寸较小且室间隔运动反向，但左心室功能正常，且似乎不会随着年龄增长、肺动脉高压或右心室衰竭的出现而恶化。异常的室间隔运动似乎通过增强的室间隔和后壁增厚百分比得到了代偿。
