Department of Guangxi Key Laboratory of AIDS Prevention and Treatment, School of Public Health, Guangxi Medical University, Nanning, China.
Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
AIDS Res Hum Retroviruses. 2024 Oct;40(10):568-574. doi: 10.1089/AID.2023.0149. Epub 2024 Apr 16.
With the prevalence of human immunodeficiency virus type 1 (HIV-1) CRF01_AE and CRF07_BC subtypes in China, the co-circulation of multiple subtypes in the HIV-1-positive population may result in dual infection or superinfection in the population, leading to the emergence of unique recombinant forms (URFs) of the HIV-1 virus. In this study, two second-generation unique recombinant strains, BI0114 and BI0116, were identified, and their near full-length genome sequences were obtained. Recombination analysis showed that both sequences were isoforms of URF_0107, and they were second-generation unique recombinant strains formed by the recombination of CRF01_AE and CRF07_BC, with the isoforms being CRF01_AE and CRF0107_BC, respectively. The continued emergence of novel CRF01_AE/CRF07_BC recombinant strains suggests that the epidemiological, preventive, and control situation of HIV-1 is complex and that the relevant health authorities urgently need to establish responses to the challenges posed by changes in the pattern of strain recombination.
随着中国人类免疫缺陷病毒 1 型（HIV-1）CRF01_AE 和 CRF07_BC 亚型的流行，HIV-1 阳性人群中多种亚型的共同循环可能导致人群中的双重感染或超感染，从而导致 HIV-1 病毒出现独特的重组形式（URFs）。在这项研究中，鉴定出了两种第二代独特重组株 BI0114 和 BI0116，并获得了它们的全长近基因组序列。重组分析表明，这两个序列都是 URF_0107 的亚型，它们是由 CRF01_AE 和 CRF07_BC 重组形成的第二代独特重组株，各自的亚型分别为 CRF01_AE 和 CRF0107_BC。新型 CRF01_AE/CRF07_BC 重组株的持续出现表明，HIV-1 的流行病学、预防和控制形势复杂，相关卫生部门急需建立应对由株重组模式变化带来的挑战的应对措施。
