Department of Nursing, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Department of Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Curr Med Sci. 2024 Apr;44(2):328-332. doi: 10.1007/s11596-024-2849-3. Epub 2024 Mar 22.
This study aimed to investigate the incidence of enteral nutrition intolerance (ENI) in patients with sepsis and explore potential risk factors.
A case-control study was conducted in patients with sepsis who were receiving enteral nutrition (EN) at a tertiary hospital in China. The included patients were divided into the ENI group and the non-ENI group. Univariate and multivariate analyses were performed to identify the risk factors for ENI.
A total of 859 patients were included in the study. Among them, 288 (33.53%) patients experienced symptoms of ENI, including diarrhea, vomiting, bloating, and gastric retention. Logistic regression analysis revealed that the Acute Physiology and Chronic Health Evaluation H (APACHE H) score, thoracocentesis, and usage of cardiotonic drugs (namely, inotropes) were independent predictors of the ENI.
The incidence of ENI is relatively high in patients with sepsis, especially in those who have higher APACHE H scores, have undergone thoracocentesis, and have received inotropes.
本研究旨在调查脓毒症患者肠内营养不耐受（ENI）的发生率，并探讨潜在的危险因素。
在中国的一家三级医院对接受肠内营养（EN）的脓毒症患者进行了病例对照研究。纳入的患者分为 ENI 组和非 ENI 组。采用单因素和多因素分析来确定 ENI 的危险因素。
共有 859 名患者纳入研究。其中，288 名（33.53%）患者出现了 ENI 症状，包括腹泻、呕吐、腹胀和胃潴留。Logistic 回归分析显示，急性生理学和慢性健康状况评分系统Ⅱ（APACHE Ⅱ）评分、胸腔穿刺术和使用正性肌力药物（即强心剂）是 ENI 的独立预测因素。
脓毒症患者的 ENI 发生率相对较高，尤其是那些 APACHE Ⅱ评分较高、接受过胸腔穿刺术和使用过强心剂的患者。
