Department of Laboratory Medicine, Changzheng Hospital, Naval Medical University, Shanghai, PR China.
Department of Laboratory Medicine, Huangyan Hospital of Wenzhou Medical University, Taizhou First People's Hospital, Taizhou, Zhejiang, PR China.
Clin Res Hepatol Gastroenterol. 2024 May;48(5):102321. doi: 10.1016/j.clinre.2024.102321. Epub 2024 Mar 20.
Many studies reported the prevalence of extrahepatic conditions (EHC) of primary biliary cholangitis (PBC), but the great heterogeneity existed across different studies. Therefore, we conducted the systematic review and meta-analyses to determine EHC prevalence and association with PBC.
We searched PUBMED and included observational, cross-sectional and case-controlled studies. A random or fixed effects model was used to estimate the pooled prevalence and odd ratio (OR) as appropriate.
Of 5370 identified publications, 129 publications with 133 studies met the inclusion criteria. Sjögren's syndrome had the highest prevalence (21.4 % vs. 3 % in non-PBC individuals), followed by Raynaud's syndrome (12.3 % vs. 1 %), rheumatoid arthritis-like arthritis (5 % vs. 3 %), systemic sclerosis (3.7 % vs. 0 %) and systemic lupus erythematosus (2 % vs. 0 %). The prevalence of overall thyroid diseases (11.3 %), autoimmune thyroid diseases (9.9 %), osteoporosis (21.1 %), celiac disease (1 %) and chronic bronchitis (4.6 %) was also increased among PBC patients.
This is the first exhaustive study on the old theme about EHC of PBC. Given increased prevalence of many EHCs in PBC patients, promptly recognizing these EHCs are of great importance for timely and precise diagnosis of PBC.
许多研究报告了原发性胆汁性胆管炎（PBC）的肝外疾病（EHC）患病率，但不同研究之间存在很大的异质性。因此，我们进行了系统评价和荟萃分析，以确定 EHC 的患病率及其与 PBC 的关联。
我们检索了 PUBMED，并纳入了观察性、横断面和病例对照研究。适当情况下，使用随机或固定效应模型估计汇总患病率和比值比（OR）。
在 5370 篇已识别的文献中，有 129 篇文献中的 133 项研究符合纳入标准。干燥综合征的患病率最高（21.4%比非 PBC 个体的 3%），其次是雷诺氏综合征（12.3%比 1%）、类风湿关节炎样关节炎（5%比 3%）、系统性硬化症（3.7%比 0%）和系统性红斑狼疮（2%比 0%）。PBC 患者的总体甲状腺疾病（11.3%）、自身免疫性甲状腺疾病（9.9%）、骨质疏松症（21.1%）、乳糜泻（1%）和慢性支气管炎（4.6%）的患病率也有所增加。
这是第一项关于 PBC 的 EHC 的详尽研究。鉴于 PBC 患者中许多 EHC 的患病率增加，及时识别这些 EHC 对于及时、准确地诊断 PBC 非常重要。
