John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.
California Animal Health and Food Safety Laboratory, University of California, Davis, CA, USA.
J Vet Diagn Invest. 2024 May;36(3):473-476. doi: 10.1177/10406387241239920. Epub 2024 Mar 23.
Gastrointestinal adenocarcinomas are often reported in South American camelids (SAC). We describe here cases of gastroduodenal adenocarcinoma in an adult alpaca () and a llama (); both SACs were anorectic and lethargic before death. At autopsy, a prominent and firm caudal C3-pyloric-duodenal junction with stricture and ulceration was present in both animals, as were hemorrhages in various organs and hydrothorax. Microscopically, scattered nests, cords, and tortuous acini of neoplastic epithelial cells were embedded in desmoplastic stroma and invaded the submucosa and muscle layers of the gastroduodenal junction. The mucosa was necrotic, with gram-negative rods in the alpaca and colonies of gram-positive cocci in the llama. No tumor metastases were observed. The neoplastic cells immunolabeled for pancytokeratin. was isolated from the alpaca and from the llama; septicemia was the cause of death in both animals. Although adenocarcinomas arising from gastric compartments and intestinal segments have been reported in SACs, adenocarcinoma of the caudal C3-pyloric-duodenal junction has not been reported previously in these species, to our knowledge.
南美驼（羊驼）和骆马的胃肠道腺癌较为常见。我们在此描述了一例成年羊驼和一例骆马发生的胃十二指肠腺癌病例；两例 SAC 死前均出现厌食和嗜睡。尸检时，两例动物的尾部 C3-幽门-十二指肠交界处均有突出且坚硬的狭窄和溃疡，各器官有出血和胸腔积水。镜下，散在的巢状、索状和扭曲的腺上皮细胞肿瘤嵌入纤维组织增生的基质中，并侵犯胃十二指肠交界处的黏膜下层和肌层。黏膜坏死，羊驼中有革兰氏阴性杆菌，骆马中有革兰氏阳性球菌菌落。未观察到肿瘤转移。肿瘤细胞免疫组化标记为广谱细胞角蛋白。从羊驼中分离出，从骆马中分离出；败血症是导致两例动物死亡的原因。据我们所知，虽然在 SAC 中已经报道了源自胃和肠段的腺癌，但在这些物种中，尾部 C3-幽门-十二指肠交界处的腺癌以前尚未报道过。
