Department of Clinical Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mol Biol Rep. 2024 Mar 23;51(1):440. doi: 10.1007/s11033-024-09371-2.
Globally, cardiovascular diseases (CVD) are one of the significant causes of death and are considered a major concern of human society. One of the most crucial objectives of scientists is to reveal the mechanisms associated with the pathogenesis of CVD, which has attracted the attention of many scientists. Accumulating evidence showed that the signal transducer and activator of transcription (STAT) signaling pathway is involved in various physiological and pathological processes. According to research on the molecular mechanisms of CVDs, the STAT family of proteins is one of the most crucial players in these diseases. Numerous studies have demonstrated the undeniable relevance of STAT family proteins in various CVDs. The aim of this review is to shed light on how STAT signaling pathways are related to CVD and the potential for using these signaling pathways as therapeutic targets.
在全球范围内，心血管疾病 (CVD) 是导致死亡的主要原因之一，被认为是人类社会的主要关注点。科学家的一个最重要目标是揭示与 CVD 发病机制相关的机制，这引起了许多科学家的关注。越来越多的证据表明，信号转导子和转录激活子 (STAT) 信号通路参与了各种生理和病理过程。根据 CVD 分子机制的研究，STAT 家族蛋白是这些疾病中最重要的参与者之一。许多研究已经证明了 STAT 家族蛋白在各种 CVD 中的不可否认的相关性。本综述的目的是阐明 STAT 信号通路与 CVD 的关系，以及将这些信号通路用作治疗靶点的潜力。
