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植物疗法治疗更年期综合征和骨质疏松症。

Phytotherapeutic approach for conquering menopausal syndrome and osteoporosis.

机构信息

Nanotechnology Lab, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi, India.

Sun Pharmaceutical Industries Limited, R&D Centre, Gurugram, India.

出版信息

Phytother Res. 2024 Jun;38(6):2728-2763. doi: 10.1002/ptr.8172. Epub 2024 Mar 24.

Abstract

Women face a significant change in their reproductive health as menopause sets in. It is marred with numerous physiological changes that negatively impact their quality of life. This universal, transition phase is associated with menopausal and postmenopausal syndrome, which may spread over 2-10 years. This creates a depletion of female hormones causing physical, mental, sexual and social problems and may, later on, manifest as postmenopausal osteoporosis leading to weak bones, causing fractures and ultimately morbidity and mortality. Menopausal hormone therapy generally encompasses the correction of hormone balance through various pharmacological agents, but the associated side effects often lead to cessation of therapy with poor clinical outcomes. However, it has been noticed that phytotherapeutics is trusted by women for the amelioration of symptoms related to menopause and for improving bone health. This could primarily be due to their reduced side effects and lesser costs. This review attempts to bring forth the suitability of phytotherapeutics/herbals for the management of menopausal, postmenopausal syndrome, and menopausal osteoporosis through several published research. It tries to enlist the available botanicals with their key constituents and mechanism of action for mitigating symptoms associated with menopause as well as osteoporosis. It also includes a list of a few herbal commercial products available for these complications. The article also intends to collate the findings of various clinical trials and patents available in this field and provide a window for newer research avenues in this highly important yet ignored health segment.

摘要

女性在进入绝经期时,其生殖健康会发生重大变化。绝经和绝经后综合征伴随着许多生理变化,会对她们的生活质量产生负面影响。这个普遍的过渡阶段可能会持续 2-10 年。这会导致女性激素的消耗,从而引发身体、心理、性和社交问题,并且可能在后期表现为绝经后骨质疏松症,导致骨骼脆弱、骨折,最终导致发病率和死亡率上升。绝经期激素治疗通常包括通过各种药物来纠正激素平衡,但相关的副作用往往会导致治疗中断,临床效果不佳。然而,人们注意到,植物疗法因其副作用较小、成本较低而受到女性的信赖,用于改善与绝经相关的症状和改善骨骼健康。这可能主要是由于它们的副作用较小和成本较低。

本篇综述通过已发表的研究,试图探讨植物疗法/草药在治疗绝经、绝经后综合征和绝经后骨质疏松症方面的适用性。它试图列出具有关键成分和作用机制的可用植物,以减轻与绝经和骨质疏松症相关的症状。它还包括一些用于这些并发症的草药商业产品的列表。

本文还旨在整理这一重要但被忽视的健康领域的现有临床试验和专利的发现,并为该领域的新研究途径提供一个窗口。

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