de Faria Isaque J S, de Almeida João P P, Marques João T
Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, Brazil.
Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, Brazil; Université de Strasbourg, INSERM U1257, CNRS UPR9022, 67084 Strasbourg, France.
Curr Opin Insect Sci. 2024 Jun;63:101194. doi: 10.1016/j.cois.2024.101194. Epub 2024 Mar 24.
Mosquitoes are vectors for arboviruses, such as dengue, Zika, and Chikungunya. Symbiotic interactions can affect the intrinsic ability of mosquitoes to acquire and transmit arboviruses, referred to as vector competence. Insect-specific viruses (ISVs) are commonly found in symbiotic associations with mosquitoes in the wild and can affect many aspects of mosquito biology. Here, we review current knowledge on the effects of symbiotic ISV-mosquito interactions on vector competence. We discuss potential mechanisms underlying these interactions and their implications for shaping new biological control strategies. Finally, we highlight the need for field data analyzing the circulation of ISVs in mosquitoes associated with mechanistic studies in the laboratory.
蚊子是登革热、寨卡病毒和基孔肯雅热等虫媒病毒的传播媒介。共生相互作用会影响蚊子获取和传播虫媒病毒的内在能力，即媒介能力。昆虫特异性病毒（ISV）在野外通常与蚊子存在共生关系，并且会影响蚊子生物学的许多方面。在此，我们综述了关于共生ISV与蚊子相互作用对媒介能力影响的现有知识。我们讨论了这些相互作用背后的潜在机制及其对制定新的生物控制策略的意义。最后，我们强调需要通过野外数据来分析与实验室机制研究相关的蚊子体内ISV的传播情况。
