Vasilakis Nikos, Tesh Robert B
Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, Center for Tropical Diseases, Institute for Human Infectious and Immunity, The University of Texas Medical Branch, Galveston, TX 77555-0609, United States.
Curr Opin Virol. 2015 Dec;15:69-74. doi: 10.1016/j.coviro.2015.08.007. Epub 2015 Aug 31.
Arthropod-borne viruses (arboviruses) are the causative agents of significant morbidity and mortality among humans and animals globally. In the past few years, the widespread adoption of next generation sequencing and metagenomics has led to a new era of virus discovery, where many novel viruses have been documented, exhibiting a restricted host-range in mosquitoes. They represent a wide-range of insect-specific viruses within the families of Bunyaviridae, Flaviviridae, Mesoniviridae, Reoviridae, Rhabdoviridae, Togaviridae, and the newly recognized taxon of Negeviruses. Collectively, their discovery has opened new vistas about the extent of viral diversity and evolution, their influence on vector competence and ability of their insect hosts to transmit human pathogens (e.g. arboviruses), and their potential development as biological control agents or novel vaccine platforms.
节肢动物传播病毒（虫媒病毒）是全球人类和动物重大发病和死亡的病原体。在过去几年中，新一代测序和宏基因组学的广泛应用开启了病毒发现的新时代，记录了许多新型病毒，这些病毒在蚊子中表现出有限的宿主范围。它们代表了布尼亚病毒科、黄病毒科、中病毒科、呼肠孤病毒科、弹状病毒科、披膜病毒科以及新确认的内格病毒分类群中的多种昆虫特异性病毒。总体而言，它们的发现为病毒多样性和进化的程度、它们对媒介能力的影响以及昆虫宿主传播人类病原体（如虫媒病毒）的能力，以及它们作为生物控制剂或新型疫苗平台的潜在发展开辟了新的视野。
