Molecular Entomology, Molecular Biology and Immunology Department, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany.
Department of Epidemiology and Biostatistics, School of Public Health, University of Health and Allied Sciences, Ho PMB 31, Ghana.
Viruses. 2019 Sep 17;11(9):873. doi: 10.3390/v11090873.
Mosquito-specific viruses (MSVs) are a subset of insect-specific viruses that are found to infect mosquitoes or mosquito derived cells. There has been an increase in discoveries of novel MSVs in recent years. This has expanded our understanding of viral diversity and evolution but has also sparked questions concerning the transmission of these viruses and interactions with their hosts and its microbiome. In fact, there is already evidence that MSVs interact with the immune system of their host. This is especially interesting, since mosquitoes can be infected with both MSVs and arthropod-borne (arbo) viruses of public health concern. In this review, we give an update on the different MSVs discovered so far and describe current data on their transmission and interaction with the mosquito immune system as well as the effect MSVs could have on an arboviruses-co-infection. Lastly, we discuss potential uses of these viruses, including vector and transmission control.
蚊特异性病毒 (MSVs) 是昆虫特异性病毒的一个子集，被发现感染蚊子或蚊子衍生细胞。近年来，新的 MSVs 的发现有所增加。这扩展了我们对病毒多样性和进化的理解，但也引发了关于这些病毒传播及其与宿主及其微生物组相互作用的问题。事实上，已经有证据表明 MSVs 与宿主的免疫系统相互作用。这尤其有趣，因为蚊子既可以感染 MSVs，也可以感染节肢动物传播（arbovirus）的公共卫生关注病毒。在这篇综述中，我们介绍了迄今为止发现的不同 MSVs，并描述了它们的传播和与蚊子免疫系统相互作用的最新数据，以及 MSVs 对 arbovirus 共感染的可能影响。最后，我们讨论了这些病毒的潜在用途，包括载体和传播控制。
