Panaiyadiyan Sridhar, Kumar Rajeev
Department of Urology, All India Institute of Medical Sciences, New Delhi, India.
Prostate Int. 2024 Mar;12(1):1-9. doi: 10.1016/j.prnil.2023.07.004. Epub 2023 Aug 4.
Nomograms help to predict outcomes in individual patients rather than whole populations and are an important part of evaluation and treatment decision making. Various nomograms have been developed in malignancies to predict and prognosticate clinical outcomes such as severity of disease, overall survival, and recurrence-free survival. In prostate cancer, nomograms were developed for determining need for biopsy, disease course, need for adjuvant therapy, and outcomes. Most of these predictive nomograms were based on Caucasian populations. Prostate cancer is significantly affected by race, and Asian men have a significantly different racial and genetic susceptibility compared to Caucasians, raising the concern in generalizability of these nomograms. We reviewed the existing literature for nomograms in prostate cancer and their application in Asian men. There are very few studies that have evaluated the applicability and validity of the existing nomograms in these men. Most have found significant differences in the performance in this population. Thus, more studies evaluating the existing nomograms in Asian men or suggesting modifications for this population are required.
列线图有助于预测个体患者而非整个人群的预后，是评估和治疗决策的重要组成部分。在恶性肿瘤领域已开发出各种列线图，用于预测和推断疾病严重程度、总生存期和无复发生存期等临床结局。在前列腺癌中，列线图用于确定活检需求、疾病进程、辅助治疗需求及预后。这些预测性列线图大多基于白种人群。前列腺癌受种族影响显著，与白种人相比，亚洲男性具有明显不同的种族和遗传易感性，这引发了对这些列线图可推广性的担忧。我们回顾了关于前列腺癌列线图及其在亚洲男性中的应用的现有文献。很少有研究评估现有列线图在这些男性中的适用性和有效性。大多数研究发现该人群中的表现存在显著差异。因此，需要更多研究来评估现有列线图在亚洲男性中的情况，或针对该人群提出修改建议。
