Kaur Manharpreet, Singla Nidhi, Aggarwal Deepak, Kundu Reetu, Gulati Neelam, Kumar Mani Bhushan, Gombar Satinder, Chander Jagdish
Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, Chandigarh, IND.
Microbiology, Government Medical College, Chandigarh, Chandigarh, IND.
Cureus. 2024 Feb 20;16(2):e54586. doi: 10.7759/cureus.54586. eCollection 2024 Feb.
species are ubiquitously found in the environment worldwide and are important causative agents for infection. Drug resistance among species is emerging, hence the present study was undertaken to look for antifungal susceptibility profiles of clinical and environmental isolates of species.
During the period from January 2018 to June 2019, a total of 102 isolates (40 clinical, 40 hospital, and 22 community environment) were tested for antifungal susceptibility testing for determination of minimum inhibitory concentration (MIC)/minimum effective concentration (MEC) as per Clinical and Laboratory Standards Institute (CLSI) M38-A3 method for itraconazole, voriconazole, amphotericin B, and caspofungin.
Out of these 102 isolates, was the most common species present. species were found to have low MIC values to azoles such as itraconazole and voriconazole except for one clinical isolate, which showed a MIC value of 2 μg/ml to voriconazole. Two isolates were non-wild-type for amphotericin B, but all isolates were wild-type for caspofungin.
Antifungal susceptibility testing among clinical isolates and environmental surveillance studies in view of emerging drug resistance should be undertaken at a larger scale.
[具体物种名称]在全球环境中普遍存在，是重要的感染病原体。[具体物种名称]的耐药性正在出现，因此开展本研究以探寻该物种临床和环境分离株的抗真菌药敏谱。
在2018年1月至2019年6月期间，共对102株[具体物种名称]分离株（40株临床分离株、40株医院分离株和22株社区环境分离株）进行抗真菌药敏试验，按照临床和实验室标准协会（CLSI）M38 - A3方法测定伊曲康唑、伏立康唑、两性霉素B和卡泊芬净的最低抑菌浓度（MIC）/最低有效浓度（MEC）。
在这102株[具体物种名称]分离株中，[具体物种名称]是最常见的物种。除1株临床分离株对伏立康唑的MIC值为2μg/ml外，[具体物种名称]对伊曲康唑和伏立康唑等唑类药物的MIC值较低。有2株分离株对两性霉素B为非野生型，但所有分离株对卡泊芬净均为野生型。
鉴于耐药性的出现，应更大规模地开展临床[具体物种名称]分离株的抗真菌药敏试验和环境监测研究。
