慢性戊型肝炎病毒感染在一名心脏移植患者中表现为转氨酶升高
Chronic Hepatitis E Virus Manifesting as Elevated Transaminases in a Heart Transplant Patient.
作者信息
Mohamed Islam, Sanders Kimberly, Hillebrand Donald J
机构信息
Department of Internal Medicine, University of Missouri-Kansas City, Kansas City, MO.
Department of Gastroenterology and Hepatology, University of Missouri-Kansas City, Kansas City, MO.
出版信息
ACG Case Rep J. 2024 Mar 22;11(3):e01308. doi: 10.14309/crj.0000000000001308. eCollection 2024 Mar.
Hepatitis E virus (HEV) is a common cause of viral hepatitis worldwide. Genotypes 1 and 2 cause acute hepatitis in endemic regions (Asia and Africa), whereas genotypes 3 and 4 (America and Europe) result in sporadic acute or chronic hepatitis, specifically in certain groups. HEV infections are rising because of increased transplantation rates and immunosuppression. We report a 75-year-old heart transplant patient with nonspecific symptoms, diagnosed with HEV chronic hepatitis. Despite ribavirin-induced hemolytic anemia, the patient achieved sustained virological response and normalization of liver enzymes.
戊型肝炎病毒（HEV）是全球病毒性肝炎的常见病因。1型和2型基因型在流行地区（亚洲和非洲）引起急性肝炎，而3型和4型基因型（美洲和欧洲）则导致散发性急性或慢性肝炎，特别是在某些特定人群中。由于移植率增加和免疫抑制，戊型肝炎病毒感染正在上升。我们报告了一名75岁的心脏移植患者，该患者有非特异性症状，被诊断为戊型肝炎慢性肝炎。尽管利巴韦林引起了溶血性贫血，但该患者实现了病毒学持续应答且肝酶恢复正常。
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