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病毒与血小板减少症

Viruses and thrombocytopenia.

作者信息

Rasizadeh Reyhaneh, Ebrahimi Fatemeh, Zamani Kermanshahi Atefeh, Daei Sorkhabi Amin, Sarkesh Aila, Sadri Nahand Javid, Bannazadeh Baghi Hossein

机构信息

Immunology Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.

Department of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Heliyon. 2024 Mar 16;10(6):e27844. doi: 10.1016/j.heliyon.2024.e27844. eCollection 2024 Mar 30.

Abstract

Thrombocytopenia, characterized by a decrease in platelet count, is a multifaceted clinical manifestation that can arise from various underlying causes. This review delves into the intriguing nexus between viruses and thrombocytopenia, shedding light on intricate pathophysiological mechanisms and highlighting the pivotal role of platelets in viral infections. The review further navigates the landscape of thrombocytopenia in relation to specific viruses, and sheds light on the diverse mechanisms through which hepatitis C virus (HCV), measles virus, parvovirus B19, and other viral agents contribute to platelet depletion. As we gain deeper insights into these interactions, we move closer to elucidating potential therapeutic avenues and preventive strategies for managing thrombocytopenia in the context of viral infections.

摘要

血小板减少症以血小板计数减少为特征,是一种可由多种潜在原因引起的多方面临床表现。本综述深入探讨了病毒与血小板减少症之间的有趣联系,揭示了复杂的病理生理机制,并强调了血小板在病毒感染中的关键作用。该综述进一步探讨了与特定病毒相关的血小板减少症情况,并阐明了丙型肝炎病毒(HCV)、麻疹病毒、细小病毒B19和其他病毒因子导致血小板减少的多种机制。随着我们对这些相互作用有更深入的了解,我们离阐明在病毒感染背景下管理血小板减少症的潜在治疗途径和预防策略又近了一步。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02e4/10957440/95c9af0658a1/gr1.jpg

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