UNC Blood Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Platelets. 2021 Apr 3;32(3):325-330. doi: 10.1080/09537104.2021.1887842. Epub 2021 Feb 22.
Platelets play an essential role in maintaining vascular integrity after injury. In addition, platelets contribute to the immune response to pathogens. For instance, they express receptors that mediate binding of viruses, and toll-like receptors that activate the cell in response to pathogen-associated molecular patterns. Platelets can be beneficial and/or detrimental during viral infections. They reduce blood-borne viruses by engulfing the free virus and presenting the virus to neutrophils. However, platelets can also enhance inflammation and tissue injury during viral infections. Here, we discuss the roles of platelets in viral infection.
血小板在损伤后维持血管完整性方面发挥着重要作用。此外，血小板有助于对病原体的免疫反应。例如，它们表达介导与病毒结合的受体，以及 Toll 样受体，以响应病原体相关分子模式激活细胞。血小板在病毒感染过程中可能有益或有害。它们通过吞噬游离病毒并将病毒呈递给中性粒细胞来减少血源病毒。然而，血小板也可以在病毒感染过程中增强炎症和组织损伤。在这里，我们讨论血小板在病毒感染中的作用。
