Minato-Inokawa Satomi, Tsuboi-Kaji Ayaka, Honda Mari, Takeuchi Mika, Kitaoka Kaori, Kurata Miki, Wu Bin, Kazumi Tsutomu, Fukuo Keisuke
Research Institute for Nutrition Sciences, Mukogawa Women's University, Nishinomiya, Hyogo Japan.
Laboratory of Community Health and Nutrition, Department of Bioscience, Graduate School of Agriculture, Ehime University, Matsuyama, Ehime, Japan.
Diabetol Int. 2024 Jan 24;15(2):270-277. doi: 10.1007/s13340-023-00689-z. eCollection 2024 Apr.
We examined whether alanine aminotransferase/aspartate aminotransferase (ALT/AST), a marker of hepatosteatosis, may be associated with a wider constellation of variables related to metabolic syndrome in Japanese women. Body fat and distribution, and metabolic syndrome-related variables were measured in 311 young and 148 middle-aged women. We had Pearson's correlation analysis and then stepwise multivariate linear regression analyses. In both middle-aged and young women, ALT/AST was associated with homeostasis model assessment insulin resistance (HOMA-IR), trunk/leg fat ratio and pulse rate. In middle-aged women but not in young women, ALT/AST was associated with waist circumference, fasting glucose, triglyceride, HDL cholesterol (inversely), systolic, diastolic and mean blood pressure (BP). Further, in middle-aged women only, the ratio was associated with BMI, percentage body fat, apolipoprotein B and plasminogen activator inhibitor-1. Among these variables, pulse rate in young women and systolic BP in middle-aged women were associated with ALT/AST independently of trunk/leg fat ratio, a sophisticated measures of abdominal fat accumulation, HOMA-IR, fasting glucose, triglyceride and HDL cholesterol. In conclusion, ALT/AST was associated with pulse rate in young women and with systolic BP in middle-aged women independently of abdominal fat accumulation and insulin resistance. It is noted that their waist circumference averaged < 80 cm and ALT < 30 U/L, suggesting minimum accumulation of abdominal and hepatic fat, respectively, key drivers of insulin resistance and metabolic syndrome.
The online version contains supplementary material available at 10.1007/s13340-023-00689-z.
我们研究了肝脂肪变性标志物丙氨酸氨基转移酶/天冬氨酸氨基转移酶（ALT/AST）是否可能与日本女性中与代谢综合征相关的更广泛变量群有关。对311名年轻女性和148名中年女性测量了体脂及其分布以及与代谢综合征相关的变量。我们进行了Pearson相关性分析，然后进行逐步多元线性回归分析。在中年和年轻女性中，ALT/AST均与稳态模型评估胰岛素抵抗（HOMA-IR）、躯干/腿部脂肪比率和脉搏率相关。在中年女性而非年轻女性中，ALT/AST与腰围、空腹血糖、甘油三酯、高密度脂蛋白胆固醇（呈负相关）、收缩压、舒张压和平均血压相关。此外，仅在中年女性中，该比率与体重指数、体脂百分比、载脂蛋白B和纤溶酶原激活物抑制剂-1相关。在这些变量中，年轻女性的脉搏率和中年女性的收缩压与ALT/AST相关，独立于躯干/腿部脂肪比率（一种复杂的腹部脂肪堆积测量指标）、HOMA-IR、空腹血糖、甘油三酯和高密度脂蛋白胆固醇。总之，ALT/AST与年轻女性的脉搏率以及中年女性的收缩压相关，独立于腹部脂肪堆积和胰岛素抵抗。值得注意的是，她们的腰围平均<80厘米且ALT<30 U/L，分别表明腹部和肝脏脂肪的最小堆积，这是胰岛素抵抗和代谢综合征的关键驱动因素。
在线版本包含可在10.1007/s13340-023-00689-z获取的补充材料。
