Jiang Liangliang, Wang Jing
Department of Gynecological Tumor, Harbin Medical University Cancer Hospital, Harbin, People's Republic of China.
Int J Gen Med. 2024 Mar 20;17:1059-1072. doi: 10.2147/IJGM.S445491. eCollection 2024.
INPP4B is a tyrosine-specific phosphatase in the human body, which plays an important role in the developing process of carcinogenesis. However, The correlation between INPP4B and epithelial ovarian cancer is rarely explored. In this study, the expression of INPP4B in human epithelial ovarian carcinoma and normal ovaries was detected, to explore the correlation between INPP4B expression and clinicopathological risk factors of epithelial ovarian carcinoma and to clarify its significance in the developing process of and prognosis of epithelial ovarian carcinoma.
The expression of INPP4B in various tumors was detected by bioinformatics method, and the expression in epithelial ovarian cancer and normal control group was detected by Elisa. The immunohistochemical method was used in this experiment to analyze the expression of INPP4B in specimens of 100 cases of epithelial ovarian carcinoma and 20 cases of normal ovaries. Analysis of clinicopathological risk factors and related survival analysis was carried out on the expression of INPP4B in 100 cases of epithelial ovarian carcinoma.
The results showed that the positive expressed INPP4B protein in epithelial ovarian carcinoma was significantly less, compared with that in normal ovaries (P < 0.05). The expression of INPP4B was significantly associated with many clinicopathologic factors, such as tumor differentiation (P < 0.001), FIGO stage (P < 0.001), lymph node metastasis (P < 0.001) and distant metastasis at recurrence (P=0. 009), but not with age, pathologic type of tumor, serum CA125 at recurrence and chemotherapy sensitivity.
In epithelial ovarian carcinoma, there is a downregulation of INPP4B expression, which may be related to poor tumor differentiation, late FIGO stage, lymph node metastasis, distant metastasis at recurrence and insensitivity to chemotherapy. Under-expression of INPP4B, lymph node metastasis, FIGO stage, and distant metastasis at recurrence are factors of poor prognostic. The under-expression level of INPP4B may be involved in the progression of epithelial ovarian carcinoma.
INPP4B是人体内一种酪氨酸特异性磷酸酶，在肿瘤发生发展过程中起重要作用。然而，INPP4B与上皮性卵巢癌之间的相关性鲜有研究。本研究检测了INPP4B在人上皮性卵巢癌组织及正常卵巢组织中的表达，以探讨INPP4B表达与上皮性卵巢癌临床病理危险因素的相关性，并阐明其在上皮性卵巢癌发生发展及预后中的意义。
采用生物信息学方法检测INPP4B在各种肿瘤中的表达，并采用酶联免疫吸附测定法检测其在上皮性卵巢癌及正常对照组中的表达。本实验采用免疫组织化学方法分析100例上皮性卵巢癌标本及20例正常卵巢标本中INPP4B的表达。对100例上皮性卵巢癌中INPP4B的表达进行临床病理危险因素分析及相关生存分析。
结果显示，上皮性卵巢癌中INPP4B蛋白阳性表达明显低于正常卵巢（P<0.05）。INPP4B的表达与多种临床病理因素显著相关，如肿瘤分化程度（P<0.001）、国际妇产科联盟（FIGO）分期（P<0.001）、淋巴结转移（P<0.001）及复发时远处转移（P=0.009），但与年龄、肿瘤病理类型、复发时血清CA125水平及化疗敏感性无关。
在上皮性卵巢癌中，INPP4B表达下调，这可能与肿瘤分化差、FIGO分期晚、淋巴结转移、复发时远处转移及化疗不敏感有关。INPP4B低表达、淋巴结转移、FIGO分期及复发时远处转移是预后不良的因素。INPP4B的低表达水平可能参与了上皮性卵巢癌的进展。
