Department of Oral Pathology and Microbiology, Sathyabama Dental College and Hospital, Sathyabama Institute of Science and Technology, Chennai 600119, India.
Meenakshi Academy of Higher Education and Research, West K.K. Nagar, Chennai 600078, India.
Dis Markers. 2024 Mar 16;2024:2264251. doi: 10.1155/2024/2264251. eCollection 2024.
The present article aims to comprehensively review the existing literature on superoxide dismutase (SOD) levels, an antioxidant enzyme, in oral cancer.
An extensive literature search was conducted across various databases, including PubMed, Wiley Online Library, Science Direct, and Cross Reference, spanning 1998-2023. At the outset, 1,177 articles were initially identified, and 907 studies were excluded due to irrelevance or duplication of the research question. Subsequently, 270 articles underwent screening evaluation, resulting in the selection of 85 articles meeting the inclusion criteria. Following this, 68 articles underwent a full-text comprehensive assessment, and ultimately, 39 were chosen for data extraction. The risk of bias in the designated articles was assessed using the Newcastle-Ottawa Scale. Finally, 13 studies were meticulously selected, offering consistent data for the ensuing meta-analysis. Meta-analysis was executed using comprehensive meta-analysis (CMA) version 3 software (Bio Stat Inc., Englewood, NJ, USA). The meta-analysis findings revealed a statistically significant decrease in SOD levels in both erythrocyte samples ( < 0.001) and tissue samples ( < 0.05) among individuals with oral cancer (OSCC) compared to the normal control group. Conversely, the analysis of three studies on salivary samples demonstrated a significant increase ( < 0.05) in SOD levels in the oral cancer group compared to the healthy controls.
This systematic review underscores a statistically significant decline in SOD levels observed across diverse bio-samples in individuals with oral cancer, indicating an excess of oxidative stress (OS). Additional research is needed to delve into the relationship between SOD levels and clinic-pathological prognostic markers within the oral cancer cohort. Such investigations have the potential to significantly contribute to the development of prognostic tools grounded in OS, thereby guiding strategies for treatment planning.
本文旨在全面综述超氧化物歧化酶（SOD）水平（一种抗氧化酶）在口腔癌中的现有文献。
在 1998 年至 2023 年期间，通过跨多个数据库（包括 PubMed、Wiley Online Library、Science Direct 和 Cross Reference）进行了广泛的文献检索。最初共确定了 1177 篇文章，其中 907 篇由于与研究问题不相关或重复而被排除。然后对 270 篇文章进行了筛选评估，最终选择了 85 篇符合纳入标准的文章。之后，对这 85 篇文章进行了全文综合评估，最终选择了 39 篇文章用于提取数据。使用纽卡斯尔-渥太华量表评估指定文章的偏倚风险。最后，精心选择了 13 项研究，为随后的荟萃分析提供了一致的数据。荟萃分析使用综合荟萃分析（CMA）版本 3 软件（Bio Stat Inc.，新泽西州恩格尔伍德）进行。荟萃分析结果显示，与正常对照组相比，口腔癌（OSCC）患者的红细胞样本（<0.001）和组织样本（<0.05）中的 SOD 水平均显著降低。然而，对 3 项唾液样本研究的分析显示，口腔癌组的 SOD 水平显著升高（<0.05），与健康对照组相比。
本系统综述强调了在口腔癌患者的各种生物样本中观察到的 SOD 水平的统计学显著下降，表明氧化应激（OS）过度。需要进一步研究以深入了解 SOD 水平与口腔癌队列中的临床病理预后标志物之间的关系。这些研究有可能为基于 OS 的预后工具的开发做出重大贡献，从而为治疗计划的制定提供策略。
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