Odelola Oluwaseyi, Akadri Adebayo
Department of Obstetrics and Gynaecology, Olabisi Onabanjo University Teaching Hospital Sagamu.
Department of Obstetrics and Gynaecology, Babcock University, Ilishan-Remo, Ogun State.
J Public Health Afr. 2024 Mar 1;14(11):1664. doi: 10.4081/jphia.2023.1664. eCollection 2023 Nov 30.
Depot-medroxyprogesterone acetate (DMPA) is a highly effective long acting reversible contraceptive. Alterations in lipid profile have been associated with use of DMPA, however there is considerable debate about how profound these effects are. Hence the aim of this study is to determine the effect of DMPA on lipid profile and the associated cardiovascular risks. This was a prospective longitudinal study conducted at the family planning clinic of Olabisi Onabanjo University Teaching Hospital Sagamu, Ogun State. Sixty eight new acceptors of DMPA who had their blood samples collected for lipid profile assays at initiation of DMPA, and then at 3 months and 6 months. Data were analyzed using SPSS version 24. After 3 months of DMPA use, there was statistically significant increase in serum Total Cholesterol (TC) concentration (P=0.022), serum Low Density Lipoprotein (LDL) concentration (P=0.033), non significant increase in serum Triglyceride (TG) concentration (P=0.150) and non-significant decrease in serum Higher Density Lipoprotein (HDL) concentration (P=0.076). However, after 6 months of DMPA use, there was statistically significant increase in serum TC concentration (P=0.002), serum LDL concentration (P=0.003), serum TG concentration (P=0.001) and significant decrease in serum HDL concentration (P=0.001). DMPA use is associated with increased serum TC, TG, LDL, and reduction in HDL after 6 months of use. These changes in lipid profile may increase the risk of cardiovascular diseases.
醋酸甲羟孕酮长效注射剂（DMPA）是一种高效的长效可逆避孕药。脂质谱的改变与使用DMPA有关，然而，这些影响的程度存在相当大的争议。因此，本研究的目的是确定DMPA对脂质谱的影响以及相关的心血管风险。这是一项在奥贡州萨加穆奥拉比西·奥纳班乔大学教学医院计划生育诊所进行的前瞻性纵向研究。68名新接受DMPA的女性在开始使用DMPA时采集血样进行脂质谱分析，然后在3个月和6个月时再次采集。使用SPSS 24版软件进行数据分析。使用DMPA 3个月后，血清总胆固醇（TC）浓度有统计学意义的升高（P=0.022），血清低密度脂蛋白（LDL）浓度有统计学意义的升高（P=0.033），血清甘油三酯（TG）浓度有非显著性升高（P=0.150），血清高密度脂蛋白（HDL）浓度有非显著性降低（P=0.076）。然而，使用DMPA 6个月后，血清TC浓度有统计学意义的升高（P=0.002），血清LDL浓度有统计学意义的升高（P=0.003），血清TG浓度有统计学意义的升高（P=0.001），血清HDL浓度有显著性降低（P=0.001）。使用DMPA 6个月后，血清TC、TG、LDL升高，HDL降低。脂质谱的这些变化可能会增加心血管疾病的风险。
