Lali P, Chandra L, Gupta R P
Department of Biochemistry, Lady Hardinge Medical College, New Delhi, India.
Contraception. 1996 Jun;53(6):363-5. doi: 10.1016/0010-7824(96)00086-8.
This study was conducted to determine the effect of depot-medroxyprogesterone acetate (DMPA) as a contraceptive on levels of serum immunoglobulins, total protein and albumin in Indian users. The recommended dose of 150 mg of DMPA by deep intramuscular injection was given to twenty parous women. Levels of serum immunoglobulins, total protein and albumin were measured prior to, and at one and three months after the injection. The levels of total protein and albumin remained unaffected. No significant changes were observed in the levels of IgA and IgM. IgG levels were increased in the first and third month after DMPA injection, and the increase in the first month was statistically significant (p = 0.019). While the serum levels of IgA, IgM, total protein and albumin were unaffected, the raised levels of IgG were indicative of improved humoral immunity in Indian DMPA users.
本研究旨在确定醋酸甲羟孕酮长效注射剂（DMPA）作为一种避孕药对印度使用者血清免疫球蛋白、总蛋白和白蛋白水平的影响。对20名经产妇给予推荐剂量150mg的DMPA进行深部肌内注射。在注射前、注射后1个月和3个月测量血清免疫球蛋白、总蛋白和白蛋白水平。总蛋白和白蛋白水平未受影响。IgA和IgM水平未观察到显著变化。DMPA注射后第1个月和第3个月IgG水平升高，且第1个月的升高具有统计学意义（p = 0.019）。虽然血清IgA、IgM、总蛋白和白蛋白水平未受影响，但IgG水平升高表明印度DMPA使用者的体液免疫得到改善。
