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综述 提取物对 Cd 毒性的改善作用:对人类健康的影响及修复策略。

An overview of the ameliorative efficacy of extract against Cd toxicity: implications for human health and remediation strategies.

机构信息

Department of Biochemistry, S. S. Faculty of Science, Mohammad Ali Jauhar University, Rampur, UP, India.

Toxicology Laboratory, Department of Zoology, Govt. Raza P. G. College, Rampur, UP, India.

出版信息

Front Public Health. 2024 Mar 8;12:1327611. doi: 10.3389/fpubh.2024.1327611. eCollection 2024.

Abstract

Rapid industrialization has led to an increase in cadmium pollution, a dangerously toxic heavy metal. Cadmium (Cd) is released into the environment through industrial processes and can contaminate air, water, and soil. This pollution poses a significant risk to human health and has become a pressing concern in many industrialized areas. Due to its extended half-life, it leads to a range of health problems, including hepato-nephritic toxicity, brain damage, and degenerative bone disorders. Intoxication alters various intracellular parameters, leading to inflammation, tissue injury, and oxidative stress within cells, which disrupts normal cellular functions and can eventually result in cell death. It has also been linked to the development of bone diseases such as osteoporosis. These adverse effects highlight the urgent need to address cadmium pollution and find effective solutions to mitigate its impact on human health. This article highlights the Cd-induced risks and the role of () extract as a source of alternative medicine in alleviating the symptoms. Numerous herbal remedies often contain certain bioactive substances, such as polyphenols and alkaloids, which have the power to mitigate these adverse effects by acting as antioxidants and lowering oxidative cell damage. Research conducted in the field of alternative medicine has revealed its enormous potential to meet demands that may be effectively used in safeguarding humans and their environment. The point of this review is to investigate whether extract, known for its bioactive substances, is being investigated for its potential to mitigate the harmful effects of cadmium on health. Further investigation is needed to fully understand its effectiveness. Moreover, it is important to explore the potential environmental benefits of using extract to reduce the negative effects of Cd. This review conducted in the field of alternative medicine has revealed its enormous potential to meet demands that could have significant implications for both human health and environmental sustainability.

摘要

工业化的快速发展导致了镉污染的增加,镉是一种毒性很强的重金属。镉(Cd)通过工业过程释放到环境中,会污染空气、水和土壤。这种污染对人类健康构成了重大威胁,已成为许多工业化地区的紧迫问题。由于其半衰期长,它会导致一系列健康问题,包括肝肾毒性、脑损伤和退行性骨病。中毒会改变各种细胞内参数,导致细胞内炎症、组织损伤和氧化应激,破坏正常的细胞功能,并最终导致细胞死亡。它还与骨质疏松等骨骼疾病的发展有关。这些不利影响凸显了应对镉污染的紧迫性,需要找到有效的解决方案来减轻其对人类健康的影响。本文重点介绍了 Cd 诱导的风险,以及()提取物作为替代医学来源在缓解这些症状方面的作用。许多草药疗法通常含有某些生物活性物质,如多酚和生物碱,它们具有抗氧化作用,可以降低氧化细胞损伤,从而减轻这些不利影响。替代医学领域的研究揭示了其巨大的潜力,可以满足有效保护人类及其环境的需求。本文的重点是研究是否()提取物作为生物活性物质的来源,正在被研究用于减轻镉对健康的有害影响。需要进一步研究以充分了解其有效性。此外,探索使用()提取物来减少 Cd 的负面影响的潜在环境效益也很重要。替代医学领域的这一综述揭示了其巨大的潜力,可以满足对人类健康和环境可持续性都有重大影响的需求。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db17/10957771/f2aef68e2d18/fpubh-12-1327611-g001.jpg

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