School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Prep Biochem Biotechnol. 2024 Oct;54(9):1107-1115. doi: 10.1080/10826068.2024.2328673. Epub 2024 Mar 25.
Traditional Chinese medicine (TCM) is often composed of a variety of natural medicines. Its composition is complex, and many of its components can not be analyzed and identified. The first step in the rational application of TCM is to successfully separate the effective components which is also a great inspiration for the development of new drugs. Among the many separation technologies of TCM, the traditional heating concentration separation technology has high energy consumption and low efficiency. As a new separation technology, membrane separation technology has the characteristics of simple operation, high efficiency, environment-friendly and so on. The separation effect of high molecular weight difference solution is better. The applications of several main membrane separation technologies such as microfiltration, nanofiltration, ultrafiltration and reverse osmosis are reviewed, the methods of restoring membrane flux after membrane fouling are discussed, and their large-scale industrial applications in the future are prospected and summarized.
中药（TCM）通常由多种天然药物组成。其成分复杂，许多成分无法进行分析和鉴定。中药合理应用的第一步是成功分离有效成分，这也是新药开发的重要启示。在中药的众多分离技术中，传统的加热浓缩分离技术能耗高、效率低。膜分离技术作为一种新型分离技术，具有操作简单、效率高、环保等特点。对高分子量差溶液的分离效果较好。综述了微滤、纳滤、超滤和反渗透等几种主要膜分离技术的应用，讨论了膜污染后恢复膜通量的方法，并对其未来在大规模工业中的应用进行了展望和总结。
