Taixing Second People's Hospital, Taizhou, 225411, China.
Jiangsu Key Laboratory for Advanced Metallic Materials, School of Materials Science and Engineering, Southeast University, Nanjing, 211189, China.
J Mater Sci Mater Med. 2024 Mar 25;35(1):22. doi: 10.1007/s10856-023-06754-y.
Biodegradable porous Mg scaffolds are a promising approach to bone repair. In this work, 3D-spherical porous Mg-1.5Zn-0.2Ca (wt.%) scaffolds were prepared by vacuum infiltration casting technology, and MgF and fluorapatite coatings were designed to control the degradation behavior of Mg-based scaffolds. The results showed that the pores in Mg-based scaffolds were composed of the main spherical pores (450-600 μm) and interconnected pores (150-200 μm), and the porosity was up to 74.97%. Mg-based porous scaffolds exhibited sufficient mechanical properties with a compressive yield strength of about 4.04 MPa and elastic modulus of appropriately 0.23 GPa. Besides, both MgF coating and fluorapatite coating could effectively improve the corrosion resistance of porous Mg-based scaffolds. In conclusion, this research would provide data support and theoretical guidance for the application of biodegradable porous Mg-based scaffolds in bone tissue engineering.
可生物降解多孔 Mg 支架是一种很有前途的骨修复方法。在这项工作中，采用真空浸渍铸造技术制备了 3D 球形多孔 Mg-1.5Zn-0.2Ca（wt.%）支架，并设计了 MgF 和氟磷灰石涂层来控制 Mg 基支架的降解行为。结果表明，Mg 基支架中的孔由主要的球形孔（450-600μm）和相互连通的孔（150-200μm）组成，孔隙率高达 74.97%。Mg 基多孔支架具有足够的力学性能，压缩屈服强度约为 4.04MPa，弹性模量适当为 0.23GPa。此外，MgF 涂层和氟磷灰石涂层都能有效提高多孔 Mg 基支架的耐腐蚀性。总之，这项研究为可生物降解多孔 Mg 基支架在骨组织工程中的应用提供了数据支持和理论指导。
