DVM graduate, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Vet Med Sci. 2024 May;10(3):e1432. doi: 10.1002/vms3.1432.
Trichomonas gallinae is a parasite that causes canker and severe loss and death, especially in young pigeons. Metronidazole (MTZ) is the recommended drug for treating avian trichomoniasis. Due to drug resistance, non-chemical alternatives, such as medicinal plant extracts, are also considered possible therapies for this disease.
This study compares the antitrichomonal effects of MTZ with extracts of Camellia sinensis and Ziziphus vulgaris on T. gallinae in vitro.
Samples of T. gallinae were taken from infected pigeons. Multi-well plates with different concentrations (5, 10, 25, 50 and 100 µg/mL) of plant extracts were used for the in vitro study.
The minimum inhibitory concentration (MIC) of C. sinensis extract was 25 µg/mL over 24 h, compared to 50 µg/mL for MTZ. The MIC value of the Z. vulgaris extracts was 50 µg/mL.
The results suggest that the extracts of Z. vulgaris and C. sinensis, as potential natural agents, could have anti-avian trichomoniasis properties. This study also shows that MTZ, C. sinensis and Z. vulgaris are equally effective in preventing the growth of T. gallinae trophozoites in the culture.
鸡滴虫是一种寄生虫，可引起溃疡和严重的损失和死亡，尤其是在幼鸽中。甲硝唑（MTZ）是治疗禽类滴虫病的推荐药物。由于耐药性，非化学替代品，如药用植物提取物，也被认为是治疗这种疾病的可能疗法。
本研究比较了 MTZ 与茶树和枣提取物对鸡滴虫在体外的抗滴虫作用。
从感染鸽子中采集鸡滴虫样本。使用含有不同浓度（5、10、25、50 和 100 µg/mL）植物提取物的多孔板进行体外研究。
与 MTZ 相比，茶树提取物的最低抑菌浓度（MIC）在 24 小时内为 25 µg/mL，而 MTZ 为 50 µg/mL。枣提取物的 MIC 值为 50 µg/mL。
结果表明，枣和茶树的提取物作为潜在的天然药物，可能具有抗禽滴虫病的特性。本研究还表明，MTZ、茶树和枣在抑制鸡滴虫滋养体在培养物中的生长方面同样有效。
