Nurs Womens Health. 2024 Jun;28(3):222-226. doi: 10.1016/j.nwh.2024.02.003. Epub 2024 Mar 22.
Hyperemesis gravidarum is the most common condition requiring hospital care for women during the first 20 weeks of pregnancy and may lead to malnutrition, dehydration, and vitamin deficiencies. Depletion of vitamins such as thiamine may result in the development of Wernicke encephalopathy, a severe neurological disorder that can increase the risk for mortality and morbidity for the mother and fetus. A lack of awareness regarding the relationship of hyperemesis gravidarum and Wernicke encephalopathy may result in delayed treatment and disease management. Glucose administration in the presence of thiamine deficiency may induce Wernicke encephalopathy; protocols are needed to ensure dextrose is used for women with hyperemesis gravidarum in times of prolonged vomiting and poor oral intake only after first administering thiamine. This article includes a discussion of best practices for thiamine supplementation with hyperemesis gravidarum and Wernicke encephalopathy.
妊娠剧吐是妊娠早期 20 周内孕妇最常见的住院治疗情况，可能导致营养不良、脱水和维生素缺乏。硫胺素等维生素的消耗可能导致威尼克脑病的发生，这是一种严重的神经系统疾病，会增加母亲和胎儿的死亡率和发病率。由于对妊娠剧吐和威尼克脑病之间关系的认识不足，可能会导致治疗和疾病管理的延误。在硫胺素缺乏的情况下给予葡萄糖可能会诱发威尼克脑病；需要制定方案以确保在长时间呕吐和口服摄入不良的情况下，仅在给予硫胺素后，才将葡萄糖用于妊娠剧吐的女性。本文讨论了妊娠剧吐和威尼克脑病时硫胺素补充的最佳实践。
