糖基 RNA 细胞表面的生理滚动。
A physiologic roll for cell surface GlycoRNAs.
机构信息
Department of Pathology, Northwestern University Feinberg School of Medicine, Ward Building, Room 3-126, 303 East Chicago Avenue, Chicago, IL 60611, United States.
出版信息
J Leukoc Biol. 2024 May 29;115(6):996-998. doi: 10.1093/jleuko/qiae073.
Abstract
Glycosylated RNA molecules that can be bound by lectins have been demonstrated on the surfaces of leukocytes, but their physiologic function(s) was not known. A recent study (PMID 38262409) demonstrates that at least 1 function is to promote capture and rolling of neutrophils in the vasculature. Of interest, the neutrophil glycosylated RNA molecules bind to P-selectin but not E-selectin.
摘要
已在白细胞表面证实存在可被凝集素结合的糖基化 RNA 分子，但它们的生理功能尚不清楚。最近的一项研究（PMID:38262409）表明，至少有一个功能是促进中性粒细胞在血管中的捕获和滚动。有趣的是，中性粒细胞糖基化 RNA 分子与 P-选择素而非 E-选择素结合。
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