Department of Obstetrics and Gynecology, University of Florida College of Medicine, Jacksonville, FL, USA.
Department of Radiology, University of Florida College of Medicine, Jacksonville, FL, USA.
J Med Case Rep. 2024 Mar 26;18(1):127. doi: 10.1186/s13256-024-04445-y.
Breast metastasis from primary ovarian cancer is rare, with an estimated frequency of 0.07%. More than 110 cases are reported in the literature of metastatic spread of ovarian cancer to the breast and axilla. This entity usually represents aggressive late disease characterized by multi-drug chemoresistance and a poor prognosis with a median survival time of 16 months. Currently no standardized treatment protocol exists for this condition.
We present a case of a 59-year-old Caucasian female with recurrent high-grade serous ovarian cancer who was diagnosed with symptomatic unilateral breast metastasis while on fourth line chemotherapy with weekly paclitaxel. She was treated with local radiation with 2300 cGy to the right breast with a complete response. She then had a subsequent recurrence in the ipsilateral breast 8 months after completion of post treatment imaging. She remains alive to date approximately 2 years after her initial diagnosis of breast metastasis on seventh line treatment.
Breast metastasis from primary ovarian cancer is rare and represents advanced disease characterized by multi-drug chemoresistance and a poor prognosis. This case describes radiation therapy as a safe, effective treatment option to improve local control and quality of life in these patients, but with limited durability of response.
原发性卵巢癌发生乳房转移较为罕见，其估计频率为 0.07%。在卵巢癌转移至乳房和腋窝的文献中，已有超过 110 例报道。这种实体通常代表侵袭性晚期疾病，具有多药化疗耐药性和预后不良的特点，中位生存时间为 16 个月。目前，针对这种情况尚无标准化的治疗方案。
我们报告了一例 59 岁的高加索女性，患有复发性高级别浆液性卵巢癌，在接受四线化疗（每周紫杉醇）时被诊断为有症状的单侧乳房转移。她接受了右乳房 2300cGy 的局部放射治疗，获得完全缓解。完成治疗后影像学检查 8 个月后，同侧乳房再次复发。自最初诊断为乳房转移以来，她已接受了第七线治疗，至今约 2 年仍存活。
原发性卵巢癌发生乳房转移较为罕见，代表晚期疾病，具有多药化疗耐药性和预后不良的特点。本病例描述了放射治疗是一种安全、有效的治疗选择，可改善这些患者的局部控制和生活质量，但反应的持久性有限。
