Medical College, Wuhan University of Science and Technology School of Medicine, Wuhan, China.
Department of Gynecology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Clin Appl Thromb Hemost. 2024 Jan-Dec;30:10760296241240747. doi: 10.1177/10760296241240747.
Deep venous thrombosis (DVT) has a significant negative impact on surgical and tumor patient's safety and quality of life. There was no specific report on the incidence and risk factors of postoperative lower extremity DVT in cervical cancer patients. Analysis of the risk factors of postoperative DVT in patients with cervical cancer is of great clinical significance for prevention and treatment. We retrospectively analyzed 309 cervical cancer patients treated by the Hubei Cervical Cancer Prevention Center and used a logistic regression model to test the risk variables of postoperative lower extremity deep venous thrombosis in cervical cancer patients. By univariate analyses, the results of the study showed that the incidence of postoperative DVT was significantly increased in cervical cancer patients complicated with old age, obesity, high preoperative plasma D-dimer level, increased preoperative triglyceride level, chronic diseases (hypertension, diabetes, and cardiovascular disease), open surgery, long operation time, intraoperative blood transfusion, advanced tumor stage, and preoperative chemotherapy/radiotherapy. Advanced age, obesity, elevated preoperative D-dimer level, high preoperative triglyceride level, and open surgery were independent risk factors for postoperative lower extremity DVT in patients with cervical cancer by multivariate regression analyses (all < .05). In gynecologic patients with cervical cancer, there is a high incidence of postoperative lower extremity DVT. Clinicians should develop systematic and comprehensive prevention and treatment measures for the risk factors to lower this morbidity and improve patient prognosis.
深静脉血栓形成（DVT）对手术和肿瘤患者的安全和生活质量有重大负面影响。目前尚无关于宫颈癌患者术后下肢 DVT 的发生率和危险因素的具体报道。分析宫颈癌患者术后 DVT 的危险因素，对预防和治疗具有重要的临床意义。我们回顾性分析了湖北省宫颈癌防治中心收治的 309 例宫颈癌患者，采用 logistic 回归模型对宫颈癌患者术后下肢深静脉血栓形成的风险变量进行检验。单因素分析结果显示，高龄、肥胖、术前血浆 D-二聚体水平升高、术前甘油三酯水平升高、合并慢性病（高血压、糖尿病、心血管疾病）、开腹手术、手术时间长、术中输血、肿瘤分期晚、术前化疗/放疗的宫颈癌患者术后 DVT 发生率明显升高。多因素回归分析结果显示，高龄、肥胖、术前 D-二聚体水平升高、术前甘油三酯水平升高和开腹手术是宫颈癌患者术后下肢 DVT 的独立危险因素（均<0.05）。妇科宫颈癌患者术后下肢 DVT 发生率较高。临床医生应针对这些危险因素制定系统、全面的预防和治疗措施，以降低发病率，改善患者预后。
