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树突状细胞在脊髓损伤中的作用。

Role of dendritic cells in spinal cord injury.

机构信息

Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Department of Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.

出版信息

CNS Neurosci Ther. 2024 Mar;30(3):e14593. doi: 10.1111/cns.14593.

DOI:10.1111/cns.14593
PMID:38528832
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10964036/
Abstract

BACKGROUND

Inflammation can worsen spinal cord injury (SCI), with dendritic cells (DCs) playing a crucial role in the inflammatory response. They mediate T lymphocyte differentiation, activate microglia, and release cytokines like NT-3. Moreover, DCs can promote neural stem cell survival and guide them toward neuron differentiation, positively impacting SCI outcomes.

OBJECTIVE

This review aims to summarize the role of DCs in SCI-related inflammation and identify potential therapeutic targets for treating SCI.

METHODS

Literature in PubMed and Web of Science was reviewed using critical terms related to DCs and SCI.

RESULTS

The study indicates that DCs can activate microglia and astrocytes, promote T-cell differentiation, increase neurotrophin release at the injury site, and subsequently reduce secondary brain injury and enhance functional recovery in the spinal cord.

CONCLUSIONS

This review highlights the repair mechanisms of DCs and their potential therapeutic potential for SCI.

摘要

背景

炎症会加重脊髓损伤（SCI），树突状细胞（DCs）在炎症反应中起着至关重要的作用。它们介导 T 淋巴细胞分化，激活小胶质细胞，并释放神经营养因子 3（NT-3）等细胞因子。此外，DCs 可以促进神经干细胞的存活，并引导其向神经元分化，对 SCI 的结果产生积极影响。

目的

本综述旨在总结 DCs 在 SCI 相关炎症中的作用，并确定治疗 SCI 的潜在治疗靶点。

方法

使用与 DCs 和 SCI 相关的关键术语在 PubMed 和 Web of Science 中检索文献。

结果

研究表明，DCs 可以激活小胶质细胞和星形胶质细胞，促进 T 细胞分化，增加损伤部位神经营养因子的释放，从而减少继发性脑损伤并增强脊髓的功能恢复。

结论

本综述强调了 DCs 的修复机制及其在 SCI 中的潜在治疗潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c03/10964036/67c86536101c/CNS-30-e14593-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c03/10964036/5cb5f038213d/CNS-30-e14593-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c03/10964036/67c86536101c/CNS-30-e14593-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c03/10964036/5cb5f038213d/CNS-30-e14593-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c03/10964036/67c86536101c/CNS-30-e14593-g003.jpg

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