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一项关于肥胖对接受初次多节段胸腰椎脊柱融合术的成人脊柱畸形患者功能结局和并发症发生率影响的年龄及性别匹配研究。

An age and sex matched study on the effect of obesity on the functional outcomes and complication rates in patients with adult spinal deformity undergoing primary multi-level thoracolumbar spinal fusion.

作者信息

Kieser David Christopher, Wyatt Michael Charles, Boissiere Louis, Hayashi Kazunori, Cawley Derek Thomas, Yilgor Caglar, Larrieu Daniel, Alanay Ahmet, Acaroglu Emre, Kleinstueck Frank, Pellisé Ferran, Perez-Grueso Francisco Javier Sanchez, Bourghli Anouar, Vital Jean-Marc, Gille Olivier, Obeid Ibrahim

机构信息

Department of Orthopaedic Surgery and Musculoskeletal Medicine, University of Otago, Christchurch School of Medicine, Christchurch, New Zealand.

L'Institut de la Colonne Vertébrale, CHU Pellegrin, Bordeaux, France.

出版信息

Ann Jt. 2022 Oct 15;7:33. doi: 10.21037/aoj-22-14. eCollection 2022.

Abstract

BACKGROUND

The objective of this study was to determine the effect of obesity on the functional outcomes and complication rates of patients with adult spinal deformity (ASD) undergoing multi-level thoracolumbar fusion.

METHODS

An age and sex matched comparison of functional outcomes [Numeric Rating Scale (NRS) back and leg scores, Core Outcome Measurement Index (COMI) back scores, Scoliosis Research Society 22 (SRS22) satisfaction and total scores, Short Form 36 (SF36) general health scores, Physical Component Score (PCS), Mental Component Score (MCS), Oswestry Disability Index (ODI) (including all domains)] at 6 months, 1, 2, 3 and 4 years and the complication rates at final follow-up between obese [body mass index (BMI) >30] and normal BMI (18.5-24.9) patients undergoing more than 3 levels of thoracolumbar fusion with a minimum 2-year follow-up. Patients who had undergone any previous spinal surgery were excluded.

RESULTS

Thirty patients were included in each arm of the study. Baseline demographics, including the number of levels fused, were similar between the groups. Estimated blood loss (EBL) was higher in obese patients (1,916 1,099 mL, P=0.001), but operative time was similar (282 320 min, P=0.351). The functional outcomes and satisfaction scores were consistently poorer in the obese group at all time-points, but their satisfaction scores were similar. Obese patients had a higher complication rate (OR 3.05, P=0.038) predominantly due to dural tears and nerve root injuries, but a similar reoperation rate.

CONCLUSIONS

In patients with ASD undergoing multi-level thoracolumbar fusion, obesity results in a higher blood loss, poorer sagittal correction, poorer post-operative functional scores and higher complication rates than patients with a normal BMI. However, obesity does not affect operative times, length of hospital stay or reoperation rates. Furthermore, patients with obesity have similar post-operative satisfaction scores to patients with normal BMIs.

摘要

背景

本研究的目的是确定肥胖对接受多节段胸腰椎融合术的成人脊柱畸形(ASD)患者功能结局和并发症发生率的影响。

方法

对年龄和性别匹配的肥胖患者[体重指数(BMI)>30]和正常BMI(18.5 - 24.9)患者进行多节段胸腰椎融合术且至少随访2年的功能结局[数字评定量表(NRS)背部和腿部评分、核心结局测量指数(COMI)背部评分、脊柱侧弯研究学会22项(SRS22)满意度和总分、简明健康状况调查量表(SF36)总体健康评分、身体成分评分(PCS)、精神成分评分(MCS)、Oswestry功能障碍指数(ODI)(包括所有领域)]在6个月、1年、2年、3年和4年时进行比较,并比较最终随访时的并发症发生率。排除既往接受过任何脊柱手术的患者。

结果

研究的每组纳入30例患者。两组间包括融合节段数在内的基线人口统计学特征相似。肥胖患者的估计失血量(EBL)较高(1,916 ± 1,099 mL,P = 0.001),但手术时间相似(282 ± 320分钟,P = 0.351)。肥胖组在所有时间点的功能结局和满意度评分始终较差,但他们的满意度评分相似。肥胖患者的并发症发生率较高(比值比3.05,P = 总038),主要原因是硬脊膜撕裂和神经根损伤,但再次手术率相似。

结论

在接受多节段胸腰椎融合术的ASD患者中,与BMI正常的患者相比,肥胖导致失血量更多、矢状面矫正效果更差术、后功能评分更差以及并发症发生率更高。然而,肥胖并不影响手术时间、住院时间或再次手术率。此外,肥胖患者的术后满意度评分与BMI正常的患者相似。

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