Baylie Temesgen, Ayelgn Tiget, Tiruneh Markeshaw, Tesfa Kibur Hunie
Department of Biomedical Science, School of Medicine, Debre Markos University, Debre Markos, Ethiopia.
Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Diabetes Metab Syndr Obes. 2024 Mar 21;17:1391-1401. doi: 10.2147/DMSO.S447659. eCollection 2024.
Obesity is defined as an abnormal or excessive accumulation of fat that increases the burden of different chronic diseases in the population. It has reached epidemic proportions and is a major risk factor for a variety of diseases, including hypertension, cardiovascular disease, type 2 diabetes, dyslipidaemia, atherosclerosis, and some malignancies. Weight gain is a result of excessive energy intake compared to energy expenditure (energy loss from metabolism and physical exercise). A ketogenic diet has a more useful effect on obesity than other diets. A ketogenic diet is a low-carbohydrate, high-fat, moderate-protein diet that induces the production of ketone bodies by mimicking the breakdown of a fasting state. The mechanism behind the ketogenic diet is still unknown, although it obviously helps people with obesity lose weight. Several pathways for the ketogenic diet effect on weight loss have been hypothesized by researchers, including reduced appetite due to effects on appetite control hormones and a possible direct appetite suppressant action of ketone bodies; reduced lipogenesis and increased lipolysis; greater metabolic efficiency; and increased metabolic costs.
肥胖被定义为脂肪的异常或过度堆积，这增加了人群中不同慢性疾病的负担。它已达到流行程度，是多种疾病的主要危险因素，包括高血压、心血管疾病、2型糖尿病、血脂异常、动脉粥样硬化和一些恶性肿瘤。体重增加是能量摄入超过能量消耗（新陈代谢和体育锻炼导致的能量损失）的结果。生酮饮食对肥胖的影响比其他饮食更有效。生酮饮食是一种低碳水化合物、高脂肪、适量蛋白质的饮食，通过模拟禁食状态下的分解过程诱导酮体的产生。尽管生酮饮食显然有助于肥胖者减肥，但其背后的机制仍然未知。研究人员推测了生酮饮食对减肥产生影响的几种途径，包括对食欲控制激素的作用导致食欲降低以及酮体可能具有直接的食欲抑制作用；脂肪生成减少和脂肪分解增加；更高的代谢效率；以及代谢成本增加。
