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健康儿童中 Sirtuin 1 血清浓度 - 性别、年龄、青春期阶段、体重和饮食的依赖性。

Sirtuin 1 serum concentration in healthy children - dependence on sex, age, stage of puberty, body weight and diet.

机构信息

Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.

Department of Paediatric Endocrinology, Medical University of Lodz, Lodz, Poland.

出版信息

Front Endocrinol (Lausanne). 2024 Mar 11;15:1356612. doi: 10.3389/fendo.2024.1356612. eCollection 2024.

DOI:10.3389/fendo.2024.1356612
PMID:38529393
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10961438/
Abstract

INTRODUCTION

Sirtuin 1 (SIRT1) is known to be involved in sensing cellular energy levels and regulating energy metabolism. This study aimed to evaluate fasting serum SIRT1 levels in healthy children, and to analyse the influence of age, sex, puberty, body weight, height, and diet on its concentration.

METHODS

47 healthy children aged 4-14 with weight and height within normal range and no chronic disease were included into the study. Fasting serum SIRT1 concentrations were estimated by Enzyme Linked Immunosorbent Assay (ELISA).

RESULTS

Results showed that serum SIRT1 concentrations in healthy children did not differ with respect to sex, age, height, weight and puberty. Whereas, it appeared that a higher frequency of fruits, vegetables and dairy products consumption was associated with an increase in serum SIRT1 levels.

DISCUSSION

Studying SIRT1 in the context of children's health may have implications for a broader understanding of growth processes, pubertal development, metabolic disorders and nutrition.

摘要

简介

Sirtuin 1（SIRT1）已知参与细胞能量水平的感知和能量代谢的调节。本研究旨在评估健康儿童的空腹血清 SIRT1 水平，并分析年龄、性别、青春期、体重、身高和饮食对其浓度的影响。

方法

本研究纳入了 47 名年龄在 4-14 岁、体重和身高在正常范围内且无慢性疾病的健康儿童。通过酶联免疫吸附测定（ELISA）来估计空腹血清 SIRT1 浓度。

结果

结果表明，健康儿童的血清 SIRT1 浓度与性别、年龄、身高、体重和青春期无关。然而，较高频率的水果、蔬菜和乳制品的摄入似乎与血清 SIRT1 水平的升高有关。

讨论

在儿童健康的背景下研究 SIRT1 可能对更广泛地理解生长过程、青春期发育、代谢紊乱和营养具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e89/10961438/bd9e82147ff8/fendo-15-1356612-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e89/10961438/35b40e0c5190/fendo-15-1356612-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e89/10961438/8bc2ec846985/fendo-15-1356612-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e89/10961438/822dbf44deda/fendo-15-1356612-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e89/10961438/adea2efedb0a/fendo-15-1356612-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e89/10961438/29ae77870781/fendo-15-1356612-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e89/10961438/bd9e82147ff8/fendo-15-1356612-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e89/10961438/35b40e0c5190/fendo-15-1356612-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e89/10961438/8bc2ec846985/fendo-15-1356612-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e89/10961438/822dbf44deda/fendo-15-1356612-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e89/10961438/adea2efedb0a/fendo-15-1356612-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e89/10961438/29ae77870781/fendo-15-1356612-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e89/10961438/bd9e82147ff8/fendo-15-1356612-g006.jpg

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