Ughade Prachi A, Shrivastava Deepti
Obstetrics and Gynaecology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & Research, Wardha, IND.
Cureus. 2024 Feb 23;16(2):e54782. doi: 10.7759/cureus.54782. eCollection 2024 Feb.
This review comprehensively examines the role of endometrial CD-138 (syndecan-1) in the context of infertility and early pregnancy. The endometrium, a dynamic tissue responsive to hormonal cues, plays a central role in fertility, and understanding the molecular intricacies governing its function is crucial. CD-138, a cell surface proteoglycan, emerges as a critical player expressed by various endometrial cell types. Our exploration encompasses a brief overview of the endometrium, introducing CD-138 as a significant molecular entity. The rationale for the review underscores the importance of elucidating endometrial factors in fertility and addresses existing knowledge gaps related to CD-138. Throughout the review, we unravel the multifaceted nature of CD-138 and its involvement in infertility, highlighting its potential as a diagnostic marker. Furthermore, insights into CD-138's role during early pregnancy, including trophoblast-endothelial interactions, are discussed. In conclusion, the findings underscore the clinical implications of CD-138, suggesting its utility in diagnostics and offering prospects for targeted therapeutic interventions. The identified knowledge gaps propel future research directions, promising to deepen our understanding of this enigmatic molecule and its transformative potential in reproductive medicine.
本综述全面探讨了子宫内膜CD - 138（多配体聚糖 - 1）在不孕症和早期妊娠中的作用。子宫内膜是一种对激素信号有反应的动态组织，在生育过程中起着核心作用，了解其功能的分子复杂性至关重要。CD - 138是一种细胞表面蛋白聚糖，是由各种子宫内膜细胞类型表达的关键因子。我们的探索包括对子宫内膜的简要概述，将CD - 138作为一个重要的分子实体进行介绍。本综述的基本原理强调了阐明生育过程中子宫内膜因素的重要性，并解决了与CD - 138相关的现有知识空白。在整个综述中，我们揭示了CD - 138的多面性及其在不孕症中的作用，突出了其作为诊断标志物的潜力。此外，还讨论了CD - 138在早期妊娠中的作用，包括滋养层与内皮细胞的相互作用。总之，研究结果强调了CD - 138的临床意义，表明其在诊断中的实用性，并为靶向治疗干预提供了前景。已确定的知识空白推动了未来的研究方向，有望加深我们对这个神秘分子的理解及其在生殖医学中的变革潜力。
