Department of Microbiology, University of Haripur, Khyber Pakhtunkhwa, 22620, Pakistan.
Department of Biotechnology, Quaid e Azam University Islamabad, Islamabad, 15320, Pakistan.
Nanomedicine (Lond). 2024 Apr;19(10):875-893. doi: 10.2217/nnm-2023-0298. Epub 2024 Mar 26.
To develop a biocompatible conjugated ciprofloxacin-PEG-FeO nanodelivery system with increased efficacy of available therapeutics in a controlled manner. FeO nanoparticles were synthesized by chemical and biological methods and modified as ciprofloxacin-PEG-FeO nanoformulations. After initial antibacterial and cytotoxicity studies, the effective and biocompatible nanoformulations was further fabricated as nanotherapeutics for studies in mouse models. Chemically synthesized ciprofloxacin-PEG-FeO nanoformulations demonstrated boosted antibacterial activity against clinically isolated bacterial strains. Nanoformulations were also found to be compatible with baby hamster kidney 21 cells and red blood cells. In studies, nanotherapeutic showed wound-healing effects with eradication of infection. The investigations indicate that the developed nanotherapeutic can eradicate localized infections and enhance wound healing with controlled cytotoxicity.
为了开发一种具有生物相容性的环丙沙星-PEG-FeO 递药系统，以可控的方式提高现有治疗药物的疗效。通过化学和生物方法合成了 FeO 纳米粒子，并将其修饰为环丙沙星-PEG-FeO 纳米制剂。在进行初步的抗菌和细胞毒性研究后，进一步将有效且具有生物相容性的纳米制剂制成纳米药物，用于小鼠模型的研究。化学合成的环丙沙星-PEG-FeO 纳米制剂表现出对临床分离菌的增强抗菌活性。纳米制剂也被发现与仓鼠肾 21 细胞和红细胞相容。在研究中，纳米药物表现出了伤口愈合的效果，并消除了感染。这些研究表明，所开发的纳米药物可以消除局部感染，并在控制细胞毒性的情况下促进伤口愈合。
