College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Key Laboratory of Environment Correlative Dietology, Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China.
J Agric Food Chem. 2024 Apr 10;72(14):7906-7918. doi: 10.1021/acs.jafc.3c09540. Epub 2024 Mar 26.
Konjac glucomannan (KGM) is a water-soluble dietary fiber and is used for weight management. However, there is a lack of research on KGM for weight management in nonobese groups and the effects of high-dose KGM supplementation on liver function. This study investigated the metabolic responses to KGM intervention in obese and nonobese mice and explored the underlying mechanisms based on lipidomics. The findings demonstrated that KGM supplementation decreased body weight and mitigated lipid metabolism disorders at the mRNA and protein levels in obese mice. In contrast, no significant impact on these parameters was observed in nonobese mice. Interestingly, KGM had a more significant impact on remodeling hepatic lipid composition in obese mice compared to nonobese mice, leading to reducing harmful lipids and increasing beneficial lipids. However, high-dose KGM increased the risk of hepatocyte bile acid toxicity in obese mice and did not promote liver antioxidant status in nonobese mice. In summary, this study identified distinct metabolic responses to KGM intervention between obese and nonobese mice, providing insights for weight management using KGM.
魔芋葡甘聚糖（KGM）是一种水溶性膳食纤维，用于体重管理。然而，对于非肥胖人群中 KGM 用于体重管理的研究以及高剂量 KGM 补充对肝功能的影响还比较缺乏。本研究基于脂质组学探究了 KGM 干预对肥胖和非肥胖小鼠的代谢反应及其潜在机制。研究结果表明，KGM 补充降低了肥胖小鼠的体重，减轻了肥胖小鼠在 mRNA 和蛋白水平的脂质代谢紊乱。相比之下，KGM 对非肥胖小鼠的这些参数没有显著影响。有趣的是，KGM 对肥胖小鼠的肝脏脂质组成重塑有更显著的影响，导致有害脂质减少，有益脂质增加。然而，高剂量的 KGM 增加了肥胖小鼠肝细胞胆汁酸毒性的风险，且没有促进非肥胖小鼠的肝脏抗氧化状态。总之，本研究鉴定出肥胖和非肥胖小鼠对 KGM 干预的不同代谢反应，为使用 KGM 进行体重管理提供了依据。
