From the Immunology Unit, Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Department of Medicine, Mount Auburn Hospital, Beth Israel Lahey Health, Cambridge, MA.
Pancreas. 2024 May 1;53(5):e434-e444. doi: 10.1097/MPA.0000000000002331. Epub 2024 Mar 13.
Despite evidence of increased incidence of early-onset pancreatic cancer (EOPC), defined as pancreatic cancer diagnosed in patients below 50 years old, and its risk factors in the Western region, global epidemiological data addressing this issue is still lacking.
Utilizing data from the Global Burden of Disease Study 2019, we aimed to conduct a comprehensive analysis of the incidence, deaths, and disability-adjusted life years (DALYs) associated with EOPC and its risk factors, including smoking, obesity, and diabetes. The analysis examined the annual percentage change (APC) over the period.
In 2019, the incidence of EOPC surpassed 35,000 cases worldwide. This burden of EOPC tends to be more prevalent in males, as well as in Europe and high SDI countries. However, there is a noticeable upward trend in the burden of EOPC in the Eastern Mediterranean. While there is a global decline in EOPC mortality attributed to smoking (APC -0.33%), there is a concerning increase in mortality associated with diabetes (APC +2.84%) and obesity (APC +2.12%).
The burden of EOPC has been increasing. The mortality is rising mainly from metabolic factors. There is an urgent need for national policy development for reducing the burden of this disease.
尽管有证据表明早发性胰腺癌（EOPC）的发病率增加，其定义为 50 岁以下患者诊断出的胰腺癌，以及其在西方地区的危险因素，但全球流行病学数据仍对此问题缺乏研究。
利用 2019 年全球疾病负担研究的数据，我们旨在全面分析 EOPC 及其危险因素（包括吸烟、肥胖和糖尿病）相关的发病率、死亡率和伤残调整生命年（DALYs）。分析考察了这期间的年度百分比变化（APC）。
2019 年，全球 EOPC 的发病率超过 35000 例。这种 EOPC 的负担在男性中更为普遍，在欧洲和高 SD 地区国家也更为普遍。然而，在东地中海地区，EOPC 的负担呈明显上升趋势。尽管由于吸烟导致的 EOPC 死亡率呈全球下降趋势（APC-0.33%），但与糖尿病（APC+2.84%）和肥胖（APC+2.12%）相关的死亡率却令人担忧地上升。
EOPC 的负担一直在增加。死亡率的上升主要归因于代谢因素。迫切需要制定国家政策来减轻这种疾病的负担。
