Caldonazo Tulio, Dell'Aquila Michele, Cancelli Gianmarco, Harik Lamia, Soletti Giovanni Jr, Fischer Johannes, Kirov Hristo, Rahouma Mohamed, Ibrahim Mudathir, Demetres Michelle, An Kevin R, Girardi Leonard, Doenst Torsten, Gaudino Mario
Department of Cardiothoracic Surgery, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA.
Interdiscip Cardiovasc Thorac Surg. 2024 Mar 29;38(4). doi: 10.1093/icvts/ivae055.
Midline sternotomy is the main surgical access for cardiac surgeries. The most prominent complication of sternotomy is sternal wound infection (SWI). The use of a thorax support vest (TSV) that limits thorax movement and ensures sternal stability has been suggested to prevent postoperative SWI.
We performed a meta-analysis to evaluate differences in clinical outcomes with and without the use of TSV after cardiac surgery in randomized trials. The primary outcome was deep SWI (DSWI). Secondary outcomes were superficial SWI, sternal wound dehiscence, and hospital length of stay (LOS). A trial sequential analysis was performed. Fixed (F) and random effects (R) models were calculated.
A total of 4 studies (3820 patients) were included. Patients who wore the TSV had lower incidence of DSWI [odds ratio (OR) = F: 0.24, 95% confidence interval (CI), 0.13-0.43, P < 0.01; R: 0.24, 0.04-1.59, P = 0.08], sternal wound dehiscence (OR = F: 0.08, 95% CI, 0.02-0.27, P < 0.01; R: 0.10, 0.00-2.20, P = 0.08) and shorter hospital LOS (standardized mean difference = F: -0.30, -0.37 to -0.24, P < 0.01; R: -0.63, -1.29 to 0.02, P = 0.15). There was no difference regarding the incidence of superficial SWI (OR = F: 0.71, 95% CI, 0.34-1.47, P = 0.35; R: 0.64, 0.10, 4.26, P = 0.42). The trial sequential analysis, however, showed that the observed decrease in DSWI in the TSV arm cannot be considered conclusive based on the existing evidence.
This meta-analysis suggests that the use of a TSV after cardiac surgery could potentially be associated with a reduction in sternal wound complications. However, despite the significant treatment effect in the available studies, the evidence is not solid enough to provide strong practice recommendations.
正中开胸术是心脏手术的主要手术入路。开胸术最突出的并发症是胸骨伤口感染(SWI)。有人建议使用限制胸部活动并确保胸骨稳定性的胸部支撑背心(TSV)来预防术后SWI。
我们进行了一项荟萃分析,以评估随机试验中心脏手术后使用TSV与未使用TSV在临床结局上的差异。主要结局是深部SWI(DSWI)。次要结局是浅表SWI、胸骨伤口裂开和住院时间(LOS)。进行了试验序贯分析。计算了固定(F)和随机效应(R)模型。
共纳入4项研究(3820例患者)。佩戴TSV的患者DSWI发生率较低[优势比(OR)=F:0.24,95%置信区间(CI),0.13 - 0.43,P < 0.01;R:0.24,0.04 - 1.59,P = 0.08],胸骨伤口裂开发生率较低(OR = F:0.08,95% CI,0.02 - 0.27,P < 0.01;R:0.10,0.00 - 2.20,P = 0.08),住院LOS较短(标准化均值差 = F:-0.30,-0.37至-0.24,P < 0.01;R:-0.63,-1.29至0.02,P = 0.15)。浅表SWI发生率无差异(OR = F:0.71,95% CI,0.34 - 1.47,P = 0.35;R:0.64,0.10,4.26,P = 0.42)。然而,试验序贯分析表明,根据现有证据,TSV组中观察到的DSWI降低不能被视为定论。
这项荟萃分析表明,心脏手术后使用TSV可能与胸骨伤口并发症的减少有关。然而,尽管在现有研究中有显著的治疗效果,但证据还不够确凿,无法提供强有力的实践建议。