ICAP at Columbia University, International Programs - Malawi, Lilongwe, Malawi.
Malaria Branch, Division of Parasitic Diseases and Malaria, National Center for Emerging and Zoonotic Infectious Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia.
Am J Trop Med Hyg. 2024 Mar 26;110(5):989-993. doi: 10.4269/ajtmh.23-0726. Print 2024 May 1.
Many SARS-CoV-2 infections are asymptomatic, thus reported cases underestimate actual cases. To improve estimates, we conducted surveillance for SARS-CoV-2 seroprevalence among pregnant women attending their first antenatal care visit (ANC1) from June 2021 through May 2022. We administered a questionnaire to collect demographic, risk factors, and COVID-19 vaccine status information and tested dried blood spots for SARS-CoV-2 antibodies. Although <1% of ANC1 participants reported having had COVID-19, monthly SARS-CoV-2 seroprevalence increased from 15.4% (95% CI: 10.5-21.5) in June 2021 to 65.5% (95% CI: 55.5-73.7) in May 2022. Although COVID-19 vaccination was available in March 2021, uptake remained low, reaching a maximum of 9.5% (95% CI: 5.7-14.8) in May 2022. Results of ANC1 serosurveillance provided prevalence estimates helpful in understanding this population case burden that was available through self-report and national case reports. To improve vaccine uptake, efforts to address fears and misconceptions regarding COVID-19 vaccines are needed.
许多 SARS-CoV-2 感染是无症状的，因此报告的病例数低估了实际病例数。为了提高估计数，我们对 2021 年 6 月至 2022 年 5 月期间首次产前保健就诊（ANC1）的孕妇进行了 SARS-CoV-2 血清流行率监测。我们采用问卷调查收集人口统计学、危险因素和 COVID-19 疫苗接种状况信息，并检测了干血斑中的 SARS-CoV-2 抗体。尽管<1%的 ANC1 参与者报告曾感染过 COVID-19，但每月 SARS-CoV-2 血清阳性率从 2021 年 6 月的 15.4%（95%CI：10.5-21.5）上升至 2022 年 5 月的 65.5%（95%CI：55.5-73.7）。尽管 2021 年 3 月就有 COVID-19 疫苗，但接种率仍然很低，在 2022 年 5 月达到最高的 9.5%（95%CI：5.7-14.8）。ANC1 血清监测结果提供了有助于了解该人群病例负担的流行率估计值，这些估计值可通过自我报告和国家病例报告获得。为了提高疫苗接种率，需要努力解决对 COVID-19 疫苗的恐惧和误解。
