Wang Jing, Li Tian Li, Chang Pei Fen, Gao Yu Qian, Fan Jia Sai, Zhang Chen Hao, Zhu Hai Yan
Beijing University of Chinese Medicine Affiliated Dongzhimen Hospital, Beijing, 100700, China.
China-Japan Friendship Hospital, Beijing, 100029, China.
Heliyon. 2024 Mar 6;10(6):e27460. doi: 10.1016/j.heliyon.2024.e27460. eCollection 2024 Mar 30.
Coronary heart disease (CHD) is the leading cause of death globally, posing a serious threat to human health. However, the current treatment approaches available for CHD fall short of the ideal results. Tongxinluo (TXL) is a traditional Chinese medicine (TCM) that has been employed in the clinical treatment of cardiovascular and cerebrovascular diseases (such as angina pectoris, stroke, etc.) in China for many years and holds great potential as a prospective treatment. TXL either as a standalone treatment or in combination with interventions recommended in CHD guidelines has been shown to be effective and well tolerated in clinical trials for CHD. Drawing on the evidence from clinical trials and experimental studies, this review will focus on the cardiovascular protective properties and related mechanisms of TXL. By searching 8 Chinese and English databases, more than 4000 articles were retrieved. These articles were categorized, then read, and finally written into this review. In this review, the pharmacological properties of TXL include regulation of blood lipids, improvement of endothelial function, anti-inflammatory, antioxidant, inhibition of apoptosis and regulation of autophagy, anti-fibrosis, promotion of angiogenesis, and modulation of exosome communication. The information provided in this review will help the reader to comprehend better the insights that TCM has developed over time in practice and provide new perspectives for the treatment of CHD.
冠心病（CHD）是全球主要的死亡原因，对人类健康构成严重威胁。然而，目前可用于冠心病的治疗方法未能达到理想效果。通心络（TXL）是一种中药，在中国已用于心血管和脑血管疾病（如心绞痛、中风等）的临床治疗多年，作为一种前瞻性治疗具有巨大潜力。在冠心病临床试验中，通心络单独治疗或与冠心病指南推荐的干预措施联合使用已被证明是有效的，且耐受性良好。基于临床试验和实验研究的证据，本综述将聚焦于通心络的心血管保护特性及相关机制。通过检索8个中英文数据库，共检索到4000多篇文章。对这些文章进行分类、阅读，最终撰写成本综述。在本综述中，通心络的药理特性包括调节血脂、改善内皮功能、抗炎、抗氧化、抑制细胞凋亡和调节自噬、抗纤维化、促进血管生成以及调节外泌体通讯。本综述提供的信息将有助于读者更好地理解中医在实践中积累的见解，并为冠心病的治疗提供新的视角。
