Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Department of Pharmacy, University of Utah Health, Salt Lake City, Utah, USA.
Antimicrob Agents Chemother. 2024 May 2;68(5):e0168623. doi: 10.1128/aac.01686-23. Epub 2024 Mar 27.
Nocardiosis typically requires a prolonged treatment duration of ≥6 months and initial combination therapy with 2-3 antibiotics. First-line regimens for nocardiosis are associated with considerable toxicity; therefore, alternative therapies are needed. Omadacycline is an aminomethylcycline with broad antimicrobial activity whose activity against species has not been formally assessed. The potency of omadacycline was evaluated against 300 clinical isolates by broth microdilution. The most common species tested were (21%), (20%), and (12%). The most common specimens were respiratory (178 isolates, 59%) and wound (57 isolates, 19%). Omadacycline minimum inhibitory concentrations (MICs) across all species ranged from 0.06 µg/mL to 8 µg/mL, with an MIC of 2 µg/mL and MIC of 4 µg/mL. The lowest MICs were found among (MIC = 0.25 µg/mL, MIC = 0.25 µg/mL), (MIC = 0.25 µg/mL, MIC = 1 µg/mL), complex (MIC = 0.5 µg/mL, MIC = 1 µg/mL), (MIC = 0.5 µg/mL, MIC = 2 µg/mL), and (MIC = 1 µg/mL, MIC = 2 µg/mL). The highest MICs were found among (MIC = 4 µg/mL, MIC = 8 µg/mL). potency differed by species among clinical isolates. Further studies are warranted to evaluate the potential clinical utility of omadacycline for nocardiosis.
奴卡菌病通常需要 ≥6 个月的长期治疗，并采用 2-3 种抗生素的初始联合治疗。奴卡菌病的一线治疗方案具有相当大的毒性；因此，需要替代疗法。奥马环素是一种具有广泛抗菌活性的氨甲基环素，其对 种的活性尚未经过正式评估。通过肉汤微量稀释法评估了奥马环素对 300 株临床分离株的抗菌活性。测试的最常见 种是 (21%)、 (20%)和 (12%)。最常见的标本是呼吸道 (178 株，59%)和伤口 (57 株，19%)。所有 种的奥马环素最低抑菌浓度 (MIC) 范围为 0.06 µg/mL 至 8 µg/mL，MIC 为 2 µg/mL，MIC 为 4 µg/mL。最低 MIC 见于 (MIC = 0.25 µg/mL，MIC = 0.25 µg/mL)、 (MIC = 0.25 µg/mL，MIC = 1 µg/mL)、 复合体 (MIC = 0.5 µg/mL，MIC = 1 µg/mL)、 (MIC = 0.5 µg/mL，MIC = 2 µg/mL)和 (MIC = 1 µg/mL，MIC = 2 µg/mL)。最高 MIC 见于 (MIC = 4 µg/mL，MIC = 8 µg/mL)。奥马环素对 临床分离株的抗菌活性因种而异。需要进一步的研究来评估奥马环素治疗奴卡菌病的潜在临床应用。
