Shimoyama Miho, Kanzaki Hiroyuki, Tohyama Syunnosuke, Ida Tomomi, Ishikawa Misao, Katsumata Yuta, Arai Chihiro, Wada Satoshi, Manase Shugo, Tomonari Hiroshi
Department of Orthodontics, School of Dental Medicine, Tsurumi University, Yokohama 230-8501, Japan.
Department of Anatomy, School of Dental Medicine, Tsurumi University, Yokohama 230-8501, Japan.
Dent J (Basel). 2024 Feb 26;12(3):49. doi: 10.3390/dj12030049.
Mandibular retrognathism occurs by insufficient mandibular growth and causes several issues, such as respiratory difficulty and diminished masticatory function. At present, functional orthodontic appliances are used for stimulating mandibular growth in pediatric cases. However, the effectiveness of functional appliances is not always stable in daily practices. A more effective, reliable, and safer therapeutic method for mandibular growth promotion would be helpful for growing mandibular retrognathism patients. As we previously discovered that nutritional supplementation of myo-inositol in growing mice specifically increases mandibular endochondral growth, we performed preclinical animal experiments in rabbits in this study. Briefly, six-week-old male Japanese white rabbits were fed with or without myo-inositol supplementation in laboratory chow until 25 weeks old, and 3D image analysis using micro CT data and histological examinations was done. Myo-inositol had no systemic effect, such as femur length, though myo-inositol specifically augmented the mandibular growth. Myo-inositol increased the thickness of mandibular condylar cartilage. We discovered that the nutritional supplementation of myo-inositol during the growth period specifically augmented mandibular growth without any systemic influence, even in rabbits. Our results suggest the possibility of clinical use of myo-inositol for augmentation of the mandibular growth in growing mandibular retrognathism patients in the future.
下颌后缩是由于下颌生长不足引起的，并会导致一些问题，如呼吸困难和咀嚼功能减退。目前，功能性正畸矫治器用于刺激小儿患者的下颌生长。然而，在日常实践中，功能性矫治器的效果并不总是稳定的。一种更有效、可靠且安全的促进下颌生长的治疗方法，将有助于患有下颌后缩的生长发育期患者。由于我们之前发现，在生长中的小鼠中补充肌醇营养可特异性增加下颌软骨内生长，因此在本研究中我们对兔子进行了临床前动物实验。简要来说，六周龄的雄性日本白兔在实验室饲料中添加或不添加肌醇进行喂养，直至25周龄，然后使用微型CT数据进行三维图像分析并进行组织学检查。肌醇没有对诸如股骨长度等产生全身性影响，尽管肌醇特异性地促进了下颌生长。肌醇增加了下颌髁突软骨的厚度。我们发现，即使在兔子中，生长期补充肌醇营养也能特异性地促进下颌生长，而无任何全身性影响。我们的结果表明，未来肌醇有可能用于临床，以促进患有下颌后缩的生长发育期患者的下颌生长。
