Satou Ryouichi, Sugihara Naoki
Department of Epidemiology and Public Health, Tokyo Dental College, Tokyo 101-0061, Japan.
Dent J (Basel). 2024 Mar 6;12(3):70. doi: 10.3390/dj12030070.
Oral mucosa inflammation can cause severe pain and interfere with eating, reducing quality of life. However, few options for self-care are available. An oral liquid bandage forms a protective film over the affected area. We aimed to assess the acid erosion risk when a newly developed oral liquid bandage (ORAPLA) is accidentally deposited on teeth and to examine the relative acid erosion risk at multiple time points of the maximum recommended duration of continuous use. ORAPLA was applied to both enamel and dentin blocks from 45 bovine anterior mandibular teeth, and an acid challenge was performed in a simulated oral cavity with artificial saliva, with one exposure cycle lasting 6 h. The enamel showed substantial defects and a decrease in Vickers hardness after nine cycles, with no change in surface roughness. Dentin showed an increase in parenchymal defects and surface roughness and a trend toward decreased Vickers hardness with increasing exposure time. We found no significant acid corrosion in enamel after up to nine times the upper limit of normal use time or in dentin after up to six times the upper limit. We conclude that the acid erosion risk due to accidental attachment to teeth is low, and in the human oral cavity with salivary buffering and remineralization, likely even lower.
口腔黏膜炎症会引发剧痛并影响进食，降低生活质量。然而，可供自我护理的选择很少。一种口腔液体绷带能在患处形成保护膜。我们旨在评估一种新研发的口腔液体绷带（ORAPLA）意外附着于牙齿时的酸蚀风险，并在连续使用的最大推荐时长的多个时间点检查相对酸蚀风险。将ORAPLA应用于45颗牛下颌前牙的牙釉质和牙本质块上，并在模拟口腔中用人造唾液进行酸蚀挑战，一个暴露周期持续6小时。经过九个周期后，牙釉质出现大量缺损且维氏硬度降低，表面粗糙度无变化。牙本质随着暴露时间增加，实质缺损和表面粗糙度增加，维氏硬度有降低趋势。我们发现，在正常使用时间上限的九倍时长内，牙釉质未出现明显酸蚀，在正常使用时间上限的六倍时长内，牙本质也未出现明显酸蚀。我们得出结论，意外附着于牙齿导致的酸蚀风险较低，而在具有唾液缓冲和再矿化功能的人类口腔中，可能风险更低。
