新型材料和技术在透明伤口敷料开发中的最新进展。

Recent advances in novel materials and techniques for developing transparent wound dressings.

机构信息

Department of Chemical and Materials Engineering, University of Alberta, Alberta T6G 1H9, Canada.

Department of Mechanical Engineering, University of Alberta, Edmonton AB T6G 2H5, Canada.

出版信息

J Mater Chem B. 2023 Jul 12;11(27):6201-6224. doi: 10.1039/d3tb00639e.

Abstract

Optically transparent wound dressings offer a range of potential applications in biomedical fields, as they allow for the monitoring of wound-healing progress without having to replace the dressing. These dressings must be impermeable to water and bacteria, yet permeable to moisture vapor and atmospheric gases in order to maintain a moist environment at the wound site. This review article provides a comprehensive overview of the types of wound dressings, novel wound-dressing materials, advanced fabrication techniques for transparent wound-dressing materials, and the key features and applications of transparent dressings for the healing process, as well as how they can improve healing outcomes. This review mainly focuses on presenting specifications of transparent polymeric wound-dressing materials, such as transparent electrospun nanofibers, transparent crosslinked hydrogels, and transparent composite films/membranes. Due to the advanced properties of electrospun nanofibers, such as large surface area, efficient incorporation of antibacterial molecules, a structure similar to the extracellular matrix, and high mechanical stability, they are often used in wound-dressing applications. We also highlight hydrogels or films for wound-healing applications, and their promotion of the healing process, provision of a moist environment and pain relief through cooling and high-water content, excellent biocompatibility, and bio-biodegradability. But as hydrogels or films fabricated with a single component have low mechanical strength and stability, recent trends have offered composite or hybrid materials to achieve typical wound-dressing requirements. Advanced wound dressings with transparency, high mechanical stability, and antimicrobial functionality are becoming a popular research avenue in the wound-dressing research field. Finally, the developmental prospects of new transparent wound-dressing materials for future research are presented.

摘要

透光性伤口敷料在生物医学领域具有广泛的潜在应用,因为它们可以在不更换敷料的情况下监测伤口愈合的进展。这些敷料必须不透水和细菌,但必须能够透过水蒸气和大气气体,以维持伤口部位的湿润环境。本文综述了伤口敷料的种类、新型伤口敷料材料、透明伤口敷料材料的先进制造技术,以及透明敷料在愈合过程中的关键特性和应用,以及它们如何改善愈合效果。本文主要侧重于介绍透明聚合物伤口敷料材料的规格,如透明电纺纳米纤维、透明交联水凝胶和透明复合薄膜/膜。由于电纺纳米纤维具有大的表面积、高效掺入抗菌分子、类似于细胞外基质的结构和高机械稳定性等先进性能,因此它们经常用于伤口敷料应用。我们还强调了水凝胶或薄膜在伤口愈合应用中的作用,以及它们通过冷却和高含水量提供湿润环境和缓解疼痛、出色的生物相容性和生物可降解性来促进愈合过程。但是,由于由单一成分制成的水凝胶或薄膜的机械强度和稳定性较低,最近的趋势是提供复合或混合材料来满足典型的伤口敷料要求。具有透明性、高机械稳定性和抗菌功能的先进伤口敷料正在成为伤口敷料研究领域的热门研究方向。最后,提出了用于未来研究的新型透明伤口敷料材料的发展前景。

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