Sordi Emiliano, Piscitelli Prisco, Albanese Carla, Melcarne Anna, Tardio Anna, Quarta Fabrizio, Greco Enrico, Miani Alessandro, Falco Andrea, De Matteis Elisabetta, Congedo Maurizio, Civino Adele
Local Health Authority ASL Le, 73100 Lecce, Italy.
Department of Experimental Medicine, University of Salento, 73100 Lecce, Italy.
Epidemiologia (Basel). 2023 Dec 21;5(1):1-10. doi: 10.3390/epidemiologia5010001.
Non-melanoma skin cancers (NMSCs) include basal cell carcinoma (BCC) and squamous-cell carcinoma (SCC), as well as a wide range of rare skin tumors. NMSCs is the most frequently diagnosed type of tumor among Caucasians. We aimed at estimating the incidence and mortality of NMSCs in the Salento area (Lecce province, Southern Italy), whose population is assumed to experience heavy and frequent sun exposure due to climatic/environmental factors, both for working and leisure activities.
We computed the incidence of NMSCs in the Province of Lecce by examining the comprehensive real-world data collected by the local cancer registry, which covers all the 830,000 inhabitants, over a period of fifteen years (from 2003 to 2017), with a focus on the latest 5 years (2013-2017) for the analysis of the different histologic morphologies of these tumors. The incidence of NMSCs has been described in terms of absolute frequencies, crude rates and age-adjusted direct standardized rates (DSR). Joinpoint analysis was used to examine temporal trends in the incidence of NMSCs and estimate annual percent changes (APCs).
During the period of 2003-2017, the incidence of NMSCs reached a direct standardized rate (DSR) of 162.62 per 100,000 in men (mortality 1.57 per 100,000) and 89.36 per 100,000 in women (mortality 0.52 per 100,000), respectively. The incidence significantly increased among both men and women across the entire period. Basal cell carcinoma (BCC), with its different morphologies, represented about 67.6% of the NMSCs in men ( = 2139 out of a total of 3161 tumors observed between 2013 and 2017) and about 75.8% of the NMSCs in women ( = 1718 out of a total of 2264 tumors from 2013 to 2017), thus accounting for the vast majority of NMSCs. The results are consistent with the literature data carried out both at national and international level.
Proper monitoring of this phenomenon through timely reporting and recording of all new NMSC cases is necessary to develop new preventive strategies.
非黑色素瘤皮肤癌（NMSCs）包括基底细胞癌（BCC）和鳞状细胞癌（SCC），以及多种罕见的皮肤肿瘤。NMSCs是白种人中最常被诊断出的肿瘤类型。我们旨在估算萨伦托地区（意大利南部莱切省）NMSCs的发病率和死亡率，由于气候/环境因素，该地区人口在工作和休闲活动中都面临大量且频繁的阳光照射。
我们通过检查当地癌症登记处收集的全面真实世界数据，计算了莱切省NMSCs的发病率。该登记处涵盖了所有83万居民，时间跨度为15年（从2003年到2017年），重点分析了最近5年（2013 - 2017年）这些肿瘤的不同组织学形态。NMSCs的发病率以绝对频数、粗率和年龄调整后的直接标准化率（DSR）来描述。采用Joinpoint分析来检查NMSCs发病率的时间趋势并估算年度百分比变化（APC）。
在2003 - 2017年期间，NMSCs的发病率在男性中达到每10万人162.62例的直接标准化率（DSR）（死亡率为每10万人1.57例），在女性中为每10万人89.36例（死亡率为每10万人0.52例）。在整个时期内，男性和女性的发病率均显著上升。基底细胞癌（BCC），无论其不同形态如何，在男性的NMSCs中占约67.6%（2013年至2017年共观察到3161例肿瘤，其中2139例为BCC），在女性的NMSCs中占约75.8%（2013年至2017年共2264例肿瘤，其中1718例为BCC），因此占NMSCs的绝大多数。这些结果与国家和国际层面的文献数据一致。
通过及时报告和记录所有新的NMSC病例来对这一现象进行适当监测，对于制定新的预防策略是必要的。
