Barbos Vlad, Feciche Bogdan, Latcu Silviu, Croitor Alexei, Dema Vlad, Bardan Razvan, Faur Flaviu Ionut, Mateescu Tudor, Novacescu Dorin, Bogdan Gherle, Cumpanas Alin Adrian
Doctoral School, Department of General Medicine, "Victor Babes" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.
Department of Urology, Emergency County Hospital Oradea, Strada Gheorghe Doja 65, 410169 Oradea, Romania.
Diseases. 2024 Mar 16;12(3):56. doi: 10.3390/diseases12030056.
This study presents a systematic review of the literature on individuals' health-related quality of life (HRQoL) following radical cystectomy for muscle-invasive bladder cancer (MIBC), utilizing the Short Form-36 Health Survey (SF-36) as a primary assessment tool. The review was designed as an exhaustive literature search across three major databases including PubMed, Scopus, and Embase up to December 2023, using the PRISMA guidelines. The selection process refined 2281 identified articles down to 11 studies meeting our inclusion criteria. These studies encompassed a diverse demographic and clinical profile of 774 participants, with follow-up durations ranging from 3 to 130 months, thereby offering insights into both short-term and long-term HRQoL outcomes. The results highlighted significant alterations in individuals' HRQoL across various domains post-radical cystectomy. Notably, the Physical Functioning (PF) and Bodily Pain (BP) domains generally scored higher, indicating a moderate to high perceived physical health status. However, the Role Physical (RP) and Role Emotional (RE) domains showed variability, reflecting the challenges in daily role fulfillment and emotional adjustment post-surgery. A marked variability in physical recovery was observed, with studies reporting significant differences in PF and RP scores between patient groups. The General Health (GH) and Vitality (VT) domains sometimes reflected perceived deteriorations, whereas the Mental Health (MH) scores suggested that many patients maintained or achieved high levels of well-being post-operatively. The conclusions drawn from this systematic review underscore the profound and multi-faceted impact of radical cystectomy on HRQoL, varying widely between studies, being influenced by geographic factors, surgical methods, and the time of evaluation. The findings emphasize the necessity for holistic patient care approaches that address both physical and emotional rehabilitation, aiming to improve HRQoL outcomes.
本研究对根治性膀胱切除术治疗肌层浸润性膀胱癌（MIBC）后个体的健康相关生活质量（HRQoL）的文献进行了系统综述，使用简短健康调查问卷（SF-36）作为主要评估工具。该综述旨在按照PRISMA指南，对截至2023年12月的三个主要数据库（包括PubMed、Scopus和Embase）进行详尽的文献检索。筛选过程将2281篇已识别文章精简至11项符合纳入标准的研究。这些研究涵盖了774名参与者的不同人口统计学和临床特征，随访时间从3个月到130个月不等，从而提供了对短期和长期HRQoL结果的见解。结果突出显示了根治性膀胱切除术后个体在各个领域的HRQoL发生了显著变化。值得注意的是，身体功能（PF）和身体疼痛（BP）领域的得分通常较高，表明身体状况的感知处于中度至高程度。然而，身体角色（RP）和情感角色（RE）领域表现出变异性，反映了术后日常角色履行和情绪调整方面的挑战。观察到身体恢复存在显著变异性，研究报告患者组之间PF和RP得分存在显著差异。总体健康（GH）和活力（VT）领域有时反映出感知到的恶化，而心理健康（MH）得分表明许多患者术后维持或达到了较高的幸福感水平。该系统综述得出的结论强调了根治性膀胱切除术对HRQoL的深刻而多方面的影响，不同研究之间差异很大，受地理因素、手术方法和评估时间的影响。研究结果强调了采取全面的患者护理方法的必要性，该方法既要解决身体康复问题，也要解决情感康复问题，旨在改善HRQoL结果。
