CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China.
Mar Drugs. 2024 Feb 29;22(3):117. doi: 10.3390/md22030117.
Seven new phenol derivatives, subversins A-E (-), subversic acid A () and -wortmannine G (); one new natural product, 4-hydroxy-7-methoxyphthalide (); and five known compounds (-) were isolated from the fungus CYH-17 collected from the Haima cold seep. The structures and absolute configurations of these compounds were determined via NMR, MS, optical rotation, electronic circular dichroism (ECD) calculation, X-ray diffraction analysis and comparison with the literature. Compounds and were two pairs of enantiomers. All compounds were tested for their α-glucosidase and acetylcholinesterase (AChE) inhibitory activity, antioxidant activity and antibacterial activity, but no obvious activity was observed among these studied compounds.
从采自海马冷泉的真菌 CYH-17 中分离得到 7 个新的酚类衍生物（subversins A-E (-)，subversic acid A () 和 -wortmannine G ()）；1 个新天然产物 4-羟基-7-甲氧基邻苯二甲酸酐（）；以及 5 个已知化合物（-）。通过 NMR、MS、旋光、电子圆二色性（ECD）计算、X 射线衍射分析和与文献的比较，确定了这些化合物的结构和绝对构型。化合物和是两对对映异构体。所有化合物均进行了α-葡萄糖苷酶和乙酰胆碱酯酶（AChE）抑制活性、抗氧化活性和抗菌活性测试，但在所研究的化合物中未观察到明显的活性。
