Harimanana Aina Nirina, Andriamandimby Soa Fy, Ranoaritiana Dany Bakoly, Randrianasolo Laurence, Irinantenaina Judickaelle, Ranoelison Nirina Nantenaina, Rafisandrantatsoa Jean Théophile, Ankasitrahana Miamina Fidy, Raherinandrasana Antso Hasina, Andriamahatana Manuela Vololoniaina, Tantely Michael Luciano, Girod Romain, Dussart Philippe, Lacoste Vincent, Randremanana Rindra Vatosoa
Epidemiology and Clinical Research Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar.
Virology Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar.
Pathogens. 2024 Mar 16;13(3):257. doi: 10.3390/pathogens13030257.
An epizootic of rift valley fever (RVF) was suspected on 21 February 2021 in various districts of Madagascar, with a lab confirmation on 1 April 2021. A cross-sectional survey aiming to detect cases of RVF in humans and to study the circulation of rift valley fever virus (RVFV) in animals was conducted from 22 April to 4 May 2021 in the district of Mananjary. Blood samples from cattle and humans were tested using serological and molecular techniques. In cattle, the circulation of RVFV was confirmed between 5 February and 4 May 2021. The positivity rates of anti-RVFV IgG and IgM were 60% and 40%, respectively. In humans, the circulation of RVFV was observed from 1 April to 5 May 2021. The positivity rate of RVFV was estimated to be 11.7% by combining the results of the molecular and serological approaches. Of the 103 individuals who agreed to participate in the survey, 3 were determined to be positive by RT-PCR, and 10 had anti-RVFV IgM. Among them, one was positive for both. Given that previous studies have reported the circulation of RVFV during inter-epidemic periods and the occurrence of outbreaks due to imported RVFV in Madagascar, our findings suggest the importance of strengthening RVF surveillance from a "One Health" perspective by conducting syndromic and risk-based surveillance at the national and regional levels.
2021年2月21日，马达加斯加各地区疑似发生裂谷热（RVF）疫情，并于2021年4月1日得到实验室确认。2021年4月22日至5月4日，在马南扎里区开展了一项横断面调查，旨在检测人类裂谷热病例并研究裂谷热病毒（RVFV）在动物中的传播情况。使用血清学和分子技术对牛和人类的血样进行了检测。在牛群中，确认2021年2月5日至5月4日期间存在RVFV传播。抗RVFV IgG和IgM的阳性率分别为60%和40%。在人类中，观察到2021年4月1日至5月5日期间存在RVFV传播。结合分子和血清学方法的结果，RVFV的阳性率估计为11.7%。在同意参与调查的103人中，3人经逆转录聚合酶链反应（RT-PCR）检测呈阳性，10人具有抗RVFV IgM。其中，1人两者均呈阳性。鉴于此前的研究报告了马达加斯加在疫情间期存在RVFV传播以及因输入性RVFV引发疫情的情况，我们的研究结果表明，从“同一健康”角度出发，通过在国家和地区层面开展症状监测和基于风险的监测来加强裂谷热监测具有重要意义。
